Neuroleptic malignant syndrome

Definitions & Key takeaways

Neuroleptic malignant syndrome is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs, which are used to treat mental health conditions, such as schizophrenia, bipolar disorder, and severe depression. Neuroleptic malignant syndrome typically presents with muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium.