Paget disease of the breast

Paget disease of the breast (PDB) is a rare, malignant, and noninvasive variant of breast cancer, which results from underlying ductal carcinoma in situ or invasive breast cancer. Symptoms of Paget disease of the breast include unilateral redness and flakiness of the skin on the nipple and areola. There may also be itching, burning, swelling, breast tenderness, and nipple discharges. Treatment may involve surgery to remove the cancerous tissue and radiotherapy and/or chemotherapy to kill any remaining cancer cells.