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Protein structure and synthesis

Summary of Protein structure and synthesis
There are hierarchical degrees of complexity in the formation of a mature, fully-folded protein. Primary structure describes a linear chain of amino acids formed by sequential peptide bonds. Secondary structure consists of backbone interactions in the polypeptide chain that are stabilized by hydrogen bonds between amino acids, forming α-helices and β-pleated sheets.  In tertiary structure, secondary structures come together and further orient themselves depending on hydrophobic interactions, ionic interactions, and disulfide bridges. Finally, quaternary structure consists of multiple tertiary structures coming together to form subunits of a larger protein. 

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Protein structure and synthesis

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High Yield Notes
12 pages
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Protein structure and synthesis

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USMLE® Step 1 style questions USMLE

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USMLE® Step 2 style questions USMLE

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A 34-year old man comes to the clinic because of fulminant liver failure following a week of dehydration and diarrhea. He says his symptoms began after a hiking trip, during which he ingested some "pleasant-tasting" mushrooms. He describes them as a specific mushroom that is known to inhibit an important enzyme responsible for making mRNA in eukaryotic cells. Which of the following enzymes was most likely inhibited in this patient?