Osmosis video - Bile synthesis disorders (NORD)

Bile synthesis disorders (NORD) are a group of rare diseases that affect the body's ability to make bile. Bile is a fluid made by the liver that helps digest and absorb fats. It contains bile salts, cholesterol, proteins, and other substances. Without proper bile synthesis, the absorption of fat-soluble vitamins such as vitamins A, D, E, and K, is impaired, leading to associated deficiencies.

There are several types of bile synthesis disorders, each with its own set of symptoms. They commonly present with jaundice (a yellow discoloration of the skin and eyes), itchy skin, fatigue, dark urine, and pale stool. Bile synthesis disorders can be life-threatening if not treated.