Video - Citric acid cycle

The citric acid cycle, also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle, is a series of chemical reactions in aerobic organisms' cells. The TCA cycle generates energy in the form of ATP from nutrients able to give acetyl-CoA molecules. These include carbohydrates, lipids, alcohol, and ketogenic amino acids. Molecules.

The citric acid cycle begins with pyruvate oxidation to acetyl-CoA by the enzyme pyruvate dehydrogenase. Acetyl-CoA is then transported into the mitochondrial matrix and enters the TCA cycle, where it is oxidized by succinyl-CoA synthase to succinyl-CoA, which is then oxidized by Succinate dehydrogenase to fumarate. Fumarate is then hydrated by fumarase to malate, and malate is oxidized by malate dehydrogenase to oxaloacetate. Oxaloacetate is then reduced by phosphoenolpyruvate carboxykinase to phosphoenolpyruvate. Phosphoenolpyruvate is then dehydrogenated by pyruvate kinase to pyruvate.