Osmosis video - Myeloproliferative neoplasms: Clinical

Myeloproliferative neoplasms (MPNs) are a group of neoplastic disorders characterized by proliferation of the bone marrow cells from the myeloid lineage. That includes red blood cells, platelets, megakaryocytes, as well as granulocytes, which include neutrophils, basophils, mast cells, and eosinophils.

Common MPNs include polycythemia vera, chronic myeloid leukemia, essential thrombocythemia, and primary myelofibrosis. Symptoms can vary depending on the specific type, but may include fatigue, shortness of breath, easy bruising, and abdominal pain.