Video - Neuromuscular blockers

Neuromuscular blockers are medications used to relax the muscles during surgical procedures and mechanical ventilation. They work by inhibiting the actions of acetylcholine on nicotinic receptors at the neuromuscular junction. Inhibition of these receptors disrupts the transmission of nerve impulses to the muscles, thus causing them to become relaxed and unable to move.

Neuromuscular blockers are divided into non-depolarizing blockers, like atracurium, vecuronium, and rocuronium; and depolarizing agents like succinylcholine. Non-depolarizing blockers work by competing with acetylcholine for receptors. They are used in mechanical ventilation and to aid in surgery. On the other hand, depolarizing agents cause prolonged stimulation and subsequent desensitization of the receptors. They can facilitate tracheal intubation or short surgical procedures.