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Rheumatic heart disease is a condition that develops as a complication of rheumatic fever, which is an inflammatory disease that can occur as a complication of streptococcal infections such as strep throat. This occurs due to the antibodies against streptococcal M proteins that cross-react with proteins in the myocardium, heart valves, joints, skin, and brain.
Rheumatic heart disease is characterized by heart tissue scarring that damages the heart valves, leading to problems such as mitral stenosis, and aortic regurgitation. Symptoms of rheumatic heart disease include shortness of breath, fatigue, chest pain, and heart palpitations. Treatment may involve antibiotics to prevent further streptococcal infections, and surgery to repair or replace damaged heart valves.
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