Osmosis video - Tumor lysis syndrome (TLS): Nursing Process (ADPIE)

Tumor lysis syndrome (TLS) is a potentially life-threatening complication that can occur in cancer patients during or shortly after cancer treatment, especially in leukemia and lymphoma. TLS occurs as a result of the killing of large numbers of tumor cells by chemotherapeutic medications. This releases large amounts of intracellular contents, such as nucleic acids and potassium, into the bloodstream after cancer cells are destroyed by chemotherapy or radiation therapy. The resulting metabolic imbalances can cause electrolyte abnormalities, acute kidney injury, and other serious complications. Treatment of TLS typically involves aggressive fluid and electrolyte management and may require dialysis in severe cases.