Gestational trophoblastic disease: Nursing

Gestational trophoblastic disease includes both benign and malignant proliferations of placental cells. At the benign end of the spectrum, there’s hydatidiform mole, also called molar pregnancy; while at the malignant end, there’s gestational trophoblastic neoplasia, which includes choriocarcinoma and trophoblastic tumors. Now, let’s quickly review the physiology of fertilization. Normally, at fertilization, a single female gamete, or the egg fuses with a single male gamete, called the sperm. Both the egg and the sperm normally have 23 chromosomes each, so half the set of human chromosomes. When combined, they give rise to a new organism, called the zygote, with 46 chromosomes. Now, the zygote undergoes repeated mitosis to produce more cells, which are grouped into the inner and the outer layer. The inner cells develop to become the embryo, whereas the outer cells, called the trophoblasts, form the embryonic part of the placenta, called the chorion, and its projections, known as chorionic villi. The chorion produces beta human chorionic gonadotropin, or beta-hCG for short, which is a hormone that helps in maintaining the pregnancy. Now, gestational trophoblastic disease is the result of genetic abnormalities that occur during fertilization, leading to abnormal proliferation of trophoblastic tissue.

Risk factors include age extremes, like younger than 16, or older than 45; a personal history of gestational trophoblastic disease; and Asian race. All right let’s switch gears and talk about pathology. Hydatidiform mole develops when a chromosomally empty egg fuses with a normal sperm. The sperm's genetic material duplicates to form 46 chromosomes. Because there are only paternal chromosomes, the mole develops into a mass of cells without any fetal parts or placenta. This is called a complete mole. An incomplete mole, on the other hand, appears when a normal egg is fertilized by two sperm, which develops 69 chromosomes. In both cases there is a proliferation and edema of the chorionic villi, which form grape-like structures that rapidly fill the uterus. These structures also secrete an excessive amount of hCG. Now, a hydatidiform mole is considered premalignant, which means it sometimes develops into a malignant invasive mole that can spread to the uterus and even metastasize. Additionally, choriocarcinoma can arise from a hydatidiform mole or independently, and is highly malignant. When it comes to complications these include preeclampsia, hemorrhage, uterine infections, sepsis, and metastasis.