Paracetamol toxicity

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Paracetamol toxicity

Tanya pharma 1

Tanya pharma 1

Sympathomimetics: Direct agonists

Sympatholytics: Alpha-2 agonists

Adrenergic antagonists: Presynaptic

Adrenergic antagonists: Alpha blockers

Adrenergic antagonists: Beta blockers

Selective serotonin reuptake inhibitors

Serotonin and norepinephrine reuptake inhibitors

Tricyclic antidepressants

Monoamine oxidase inhibitors

Atypical antidepressants

Typical antipsychotics

Atypical antipsychotics

Nonbenzodiazepine anticonvulsants

Anticonvulsants and anxiolytics: Barbiturates

Anticonvulsants and anxiolytics: Benzodiazepines

Psychomotor stimulants

ACE inhibitors, ARBs and direct renin inhibitors

Thiazide and thiazide-like diuretics

Calcium channel blockers

cGMP mediated smooth muscle vasodilators

Class I antiarrhythmics: Sodium channel blockers

Class II antiarrhythmics: Beta blockers

Class III antiarrhythmics: Potassium channel blockers

Class IV antiarrhythmics: Calcium channel blockers and others

Lipid-lowering medications: Statins

Lipid-lowering medications: Fibrates

Miscellaneous lipid-lowering medications

Positive inotropic medications

Glucocorticoids

Protein synthesis inhibitors: Aminoglycosides

Antimetabolites: Sulfonamides and trimethoprim

Antituberculosis medications

Miscellaneous cell wall synthesis inhibitors

Protein synthesis inhibitors: Tetracyclines

Cell wall synthesis inhibitors: Penicillins

Miscellaneous protein synthesis inhibitors

Cell wall synthesis inhibitors: Cephalosporins

DNA synthesis inhibitors: Metronidazole

DNA synthesis inhibitors: Fluoroquinolones

Mechanisms of antibiotic resistance

Miscellaneous antifungal medications

Acetaminophen (Paracetamol)

Non-steroidal anti-inflammatory drugs

Opioid agonists, mixed agonist-antagonists and partial agonists

Migraine medications

Anti-parkinson medications

Medications for neurodegenerative diseases

Opioid antagonists

Osmotic diuretics

Carbonic anhydrase inhibitors

Potassium sparing diuretics

Paracetamol toxicity

Serotonin syndrome

Neuroleptic malignant syndrome

General anesthetics

Local anesthetics

Neuromuscular blockers

Bronchodilators: Beta 2-agonists and muscarinic antagonists

Bronchodilators: Leukotriene antagonists and methylxanthines

Pulmonary corticosteroids and mast cell inhibitors

Anticoagulants: Heparin

Anticoagulants: Warfarin

Anticoagulants: Direct factor inhibitors

Antiplatelet medications

Hypoglycemics: Insulin secretagogues

Miscellaneous hypoglycemics

Hepatitis medications

Introduction to pharmacology

Pharmacodynamics: Drug-receptor interactions

Pharmacodynamics: Agonist, partial agonist and antagonist

Pharmacodynamics: Desensitization and tolerance

Pharmacokinetics: Drug absorption and distribution

Pharmacokinetics: Drug metabolism

Pharmacokinetics: Drug elimination and clearance

Drug administration and dosing regimens

Integrase and entry inhibitors

Nucleoside reverse transcriptase inhibitors (NRTIs)

Protease inhibitors

Non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Neuraminidase inhibitors

Herpesvirus medications

Anthelmintic medications

Anti-mite and louse medications

Estrogens and antiestrogens

Progestins and antiprogestins

Androgens and antiandrogens

Aromatase inhibitors

Uterine stimulants and relaxants

PDE5 inhibitors

Adrenal hormone synthesis inhibitors

Mineralocorticoids and mineralocorticoid antagonists

Hyperthyroidism medications

Hypothyroidism medications

Acid reducing medications

Laxatives and cathartics

Key Takeaways

Paracetamol toxicity, also known as acetaminophen toxicity, is caused by excessive use or overdose of the analgesic drug paracetamol, also known as acetaminophen in North America. Paracetamol toxicity can lead to liver damage and, in severe cases, liver failure.

People with paracetamol toxicity present with nausea, vomiting, abdominal pain, and jaundice. Treatment may involve administering N-acetylcysteine within 8 hours of the ingestion. It can also involve hemodialysis and liver transplant in case of severe liver damage.