Skin cancer screening: Clinical sciences

1,294views

Skin cancer screening: Clinical sciences

Watch later

Watch later

Attention deficit hyperactivity disorder (ADHD): Clinical sciences
Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD): Clinical sciences
Alcohol use disorder: Clinical sciences
Alcohol withdrawal: Clinical sciences
Selective serotonin reuptake inhibitors
Atypical antidepressants
Monoamine oxidase inhibitors
Serotonin and norepinephrine reuptake inhibitors
Tricyclic antidepressants
Atypical antipsychotics
Typical antipsychotics
Anticonvulsants and anxiolytics: Benzodiazepines
Nonbenzodiazepine anticonvulsants
Psychomotor stimulants
Malaria: Clinical sciences
Sickle cell disease: Clinical sciences
Multiple myeloma: Clinical sciences
Zika virus
Dengue virus
Human T-lymphotropic virus
Trichuris trichiura (Whipworm)
Ancylostoma duodenale and Necator americanus
Babesia
Plasmodium species (Malaria)
Diphyllobothrium latum
Anticoagulants: Warfarin
Anticoagulants: Direct factor inhibitors
Anticoagulants: Heparin
Antimalarials
Antiplatelet medications
Thrombolytics
Hematopoietic medications
Dyslipidemia: Clinical sciences
Congestive heart failure: Clinical sciences
Infectious endocarditis: Clinical sciences
Cardiovascular disease screening: Clinical sciences
Deep vein thrombosis: Clinical sciences
Vasculitis: Pathology review
Adrenergic antagonists: Beta blockers
Calcium channel blockers
cGMP mediated smooth muscle vasodilators
Class I antiarrhythmics: Sodium channel blockers
Class II antiarrhythmics: Beta blockers
Class III antiarrhythmics: Potassium channel blockers
Class IV antiarrhythmics: Calcium channel blockers and others
ACE inhibitors, ARBs and direct renin inhibitors
Thiazide and thiazide-like diuretics
Lipid-lowering medications: Fibrates
Lipid-lowering medications: Statins
Miscellaneous lipid-lowering medications
Pheochromocytoma: Clinical sciences
Adrenal insufficiency: Clinical sciences
Primary aldosteronism (hyperaldosteronism): Clinical sciences
Multiple endocrine neoplasia: Clinical sciences
Hyperparathyroidism: Clinical sciences
Syndrome of inappropriate antidiuretic hormone secretion: Clinical sciences
Neuroendocrine tumors of the gastrointestinal system: Pathology review
Hypopituitarism: Pathology review
Pituitary tumors: Pathology review
Hyperthyroidism: Pathology review
Hypothyroidism medications
Alcohol-induced hepatitis: Clinical sciences
Cirrhosis: Clinical sciences
Gastroesophageal reflux disease: Clinical sciences
Acute pancreatitis: Clinical sciences
Pilonidal disease: Clinical sciences
Hemorrhoids: Clinical sciences
Perianal abscess and fistula: Clinical sciences
Anal fissure: Clinical sciences
Appendicitis: Clinical sciences
Diverticulitis: Clinical sciences
Irritable bowel syndrome: Clinical sciences
Gastritis: Clinical sciences
Peptic ulcer disease: Clinical sciences
Stress ulcers: Clinical sciences
Celiac disease: Clinical sciences
Inflammatory bowel disease (ulcerative colitis): Clinical sciences
Inflammatory bowel disease (Crohn disease): Clinical sciences
Infectious gastroenteritis: Clinical sciences
Esophageal cancer: Clinical sciences
Anal cancer: Clinical sciences
Colorectal cancer: Clinical sciences
Gastric cancer: Clinical sciences
Femoral hernias: Clinical sciences
Umbilical hernias: Clinical sciences
Inguinal hernias: Clinical sciences
Helicobacter pylori
Vibrio cholerae (Cholera)
Colorectal polyps and cancer: Pathology review
Acid reducing medications
Antidiarrheals
Hepatitis medications
Laxatives and cathartics
Well-patient care (adult): Clinical sciences
Well-patient care (GYN): Clinical sciences
Breast cancer screening: Clinical sciences
Carotid artery stenosis screening: Clinical sciences
Cervical cancer screening: Clinical sciences
Colorectal cancer screening: Clinical sciences
Sexually transmitted infection screening (GYN): Clinical sciences
Skin cancer screening: Clinical sciences
Anaphylaxis: Clinical sciences
Glucocorticoids
Non-corticosteroid immunosuppressants and immunotherapies
Hemochromatosis: Clinical sciences
Henoch-Schonlein purpura: Clinical sciences
Systemic lupus erythematosus: Clinical sciences
Reactive arthritis: Clinical sciences
Temporal arteritis: Clinical sciences
Systemic sclerosis (scleroderma): Clinical sciences
Infectious mononucleosis: Clinical sciences
Lyme disease: Clinical sciences
Burns: Clinical sciences
Hypothermia: Clinical sciences
Yellow fever virus
Seronegative and septic arthritis: Pathology review
Water-soluble vitamin deficiency and toxicity: B1-B7: Pathology review
Fat-soluble vitamin deficiency and toxicity: Pathology review
Water-soluble vitamin deficiency and toxicity: B9, B12 and vitamin C: Pathology review
Zinc deficiency and protein-energy malnutrition: Pathology review
Environmental and chemical toxicities: Pathology review
Antimetabolites: Sulfonamides and trimethoprim
Cell wall synthesis inhibitors: Cephalosporins
Cell wall synthesis inhibitors: Penicillins
DNA synthesis inhibitors: Metronidazole
DNA synthesis inhibitors: Fluoroquinolones
Miscellaneous cell wall synthesis inhibitors
Miscellaneous protein synthesis inhibitors
Protein synthesis inhibitors: Aminoglycosides
Protein synthesis inhibitors: Tetracyclines
Azoles
Anthelmintic medications
Herpesvirus medications
Osteoporosis: Clinical sciences
Mechanical back pain: Clinical sciences
Gout: Clinical sciences
Calcium pyrophosphate deposition disease (pseudogout): Clinical sciences
Osteoarthritis: Clinical sciences
Inflammatory myopathies: Clinical sciences
Osteomyelitis: Clinical sciences
Septic arthritis: Clinical sciences
Compartment syndrome: Clinical sciences
Anatomy clinical correlates: Bones, joints and muscles of the back
Anatomy clinical correlates: Knee
Anatomy clinical correlates: Leg and ankle
Antigout medications
Osteoporosis medications
Subarachnoid hemorrhage: Clinical sciences
Otitis media and externa (pediatrics): Clinical sciences
Multiple sclerosis: Clinical sciences
Myasthenia gravis: Clinical sciences
West Nile virus
Adult brain tumors: Pathology review
Local anesthetics
Migraine medications
Adrenergic antagonists: Alpha blockers
Medications for neurodegenerative diseases
Preconception care: Clinical sciences
Antepartum care (first trimester): Clinical sciences
Antepartum care (second trimester): Clinical sciences
Antepartum care (third trimester): Clinical sciences
Cytomegalovirus (CMV), parvovirus B19, varicella zoster, and toxoplasmosis infection in pregnancy: Clinical sciences
Group B streptococcus (GBS) colonization in pregnancy: Clinical sciences
Herpes simplex virus infection in pregnancy: Clinical sciences
Anemia in pregnancy: Clinical sciences
Early pregnancy loss: Clinical sciences
Ectopic pregnancy: Clinical sciences
Nausea and vomiting of pregnancy: Clinical sciences
Therapeutic and induced abortions: Clinical sciences
Asthma in pregnancy: Clinical sciences
Urinary tract infections and kidney stones in pregnancy: Clinical sciences
Venous thromboembolism in pregnancy: Clinical sciences
Estrogens and antiestrogens
Progestins and antiprogestins
Lower urinary tract infection: Clinical sciences
Pyelonephritis: Clinical sciences
Approach to acute kidney injury: Clinical sciences
Chronic kidney disease: Clinical sciences
Nephrolithiasis: Clinical sciences
BK virus (Hemorrhagic cystitis)
Fibroadenoma: Clinical sciences
Fibrocystic breast changes: Clinical sciences
Breast papilloma: Clinical sciences
Infertility: Clinical sciences
Uterine leiomyoma: Clinical sciences
Perimenopause, menopause, and primary ovarian insufficiency: Clinical sciences
Benign prostatic hypertrophy and prostate cancer: Clinical sciences
Testicular cancer: Clinical sciences
Benign breast conditions: Pathology review
Penile conditions: Pathology review
PDE5 inhibitors
Asthma: Clinical sciences
Sleep apnea: Clinical sciences
Coxiella burnetii (Q fever)
Legionella pneumophila (Legionnaires disease and Pontiac fever)
Pleural effusion, pneumothorax, hemothorax and atelectasis: Pathology review
Antihistamines for allergies
Bronchodilators: Beta 2-agonists and muscarinic antagonists
Bronchodilators: Leukotriene antagonists and methylxanthines
Pulmonary corticosteroids and mast cell inhibitors
Benign skin lesions: Clinical sciences
Chest X-ray interpretation: Clinical sciences

Decision-Making Tree

Transcript

Watch video only

Skin cancer is one of the most common cancers in the United States. It is estimated one in five individuals will develop some form of skin cancer within their lifetime. So, prevention is the most important way to limit the risk of developing skin cancer. Some of the most effective preventative methods include decreasing exposure to UV rays from sunlight by wearing sun-protective clothing and using broad spectrum waterproof sunscreen with an SPF of 30 or higher, as well as avoiding artificial UV rays like tanning beds. Because complete avoidance of UV rays is are not feasible, regular skin cancer screenings, which include risk factors assessments and skin exams, are used to identify individuals more susceptible for developing skin cancer.

Alright, when a patient presents for a skin cancer screening, the initial step is to assess their risk factors for future skin cancer. Individuals at an increased risk for developing skin cancer include those who are older than 50 years; as well as sun-sensitive individuals with red or blonde hair, light eye color, light skin pigmentation, or freckling.

Other important risk factors include a nevi count that is greater than 50 with or without large, atypical nevi; as well as personal or family history of skin cancer; and immunosuppression or chronic immunosuppressive therapy. Lastly, there’s an increased risk for skin cancer in patients with certain syndromes and genetic disorders, such as xeroderma pigmentosum or albinism.

Now, if your patient does not have any of the risk factors mentioned above, then they are considered to be at low risk of developing skin cancer and no routine screening examination is recommended. Keep in mind, however, any suspicious skin lesions on these patients should be checked regularly by their primary care physicians or evaluated by a dermatologist.

On the other hand, if your patient has any of the risk factors mentioned previously, they are considered to be at a high risk for developing skin cancer. These individuals should undergo annual screenings, which include a total body skin examination with a source of bright light and a magnifying lens.

Trained physicians may also use a dermatoscope, which is a tool that can magnify skin lesions and emit a special light to help detect features that are not visible to the naked eye. For example, a dermatoscope can show you subsurface skin structures within the epidermis, dermoepidermal junction and the papillary dermis. Visualizing these structures can increase the diagnostic accuracy of suspicious lesions.

Now, let’s talk about the physical examination. During the total body skin exam, the scalp, face, head, neck, arms, hands, and axillae are assessed for any lesions. Make sure to examine your patient in the supine position while inspecting the chest, abdomen, lower extremities, and toe webs; and prone position when evaluating the back, buttocks, lower extremities, and soles of the feet.

Sources

  1. "Screening for skin cancer: US Preventive Services Task Force Recommendation Statement" JAMA (2023)
  2. "Identifying individuals at high risk of melanoma: A practical predictor of absolute risk" J Clin Oncol (2006)
  3. "Approach to Skin Diseases" Goldman-Cecil Medicine, 26th ed (2015)
  4. "UV Exposure and the Risk of Cutaneous Melanoma in Skin of Color: A Systematic Review" JAMA Dermatology (2021)
  5. "Screening, early detecting, education, and trends for melanoma: Current status (2007-2013) and future directions: Part I. Epidemiology, high-risk groups, clinical strategies, and diagnostic technology" J Am Acad Dermatol (2014)