Video - Thiazide and thiazide-like diuretics

Thiazide and thiazide-like diuretics are a class of medications used to treat hypertension and edema by promoting the elimination of salt and water from the body. Thiazide diuretics work by inhibiting reabsorption, specifically by blocking the sodium-chloride symporter in the distal convoluted tubule in the kidney. This in turn leads to increased excretion of sodium and water.

The most commonly used thiazides are chlorothiazide and hydrochlorothiazide; and the most commonly used thiazide-like diuretics are metolazone, indapamide, and chlorthalidone. Thiazide and thiazide-like diuretics are generally considered safe and effective drugs for treating high blood pressure and edema. However, they can cause some side effects such as electrolyte imbalances, dehydration, increased blood sugar levels, and increased uric acid levels.