Bunions may develop due to a variety of biological or environmental factors, including arthritis, biomechanical factors, neuromuscular disorders, genetic disorders, and trauma.
Arthritic conditions, such as rheumatoid arthritis, typically cause inflammation of many joints in the body and may affect the MTP joint. Long-term inflammation can lead to deterioration of the bones that make up the MTP joint, allowing the bones to shift and form a bunion over time.
Biomechanical formation of bunions generally occurs due to excessive pronation, or turning the foot inward. Excessive pronation may occur as a result of the shape of an individual’s foot, such as flat-footedness, or may also occur when wearing high heels or tight shoes.
Neuromuscular diseases, or disorders that impair an individual's nerve and muscular function (e.g., cerebral palsy), can cause uncontrolled foot movements that may loosen the MTP joint, increasing the risk of bunion formation.
Genetic disorders, which are passed down from parents to children, can affect the tissue that connects bones (i.e., ligaments) throughout the body, including the MTP joint ligament. These disorders, which include Ehlers-Danlos syndrome, Down syndrome, and Marfan syndrome, can subsequently lead to bunion development.
Finally, trauma to the foot, specifically resulting in amputation of the second toe, can create space for the phalange of the big toe to move towards the remaining toes and create a bunion.