The causes of face blindness differ depending on the type of face blindness. Developmental face blindness is a congenital disorder, in which individuals are born with an inability to develop face recognition skills despite having unimpaired vision and memory. While there is no presence of obvious brain lesions, several studies have revealed that these individuals may have anatomical differences in regions of the brain associated with face processing, like the fusiform gyrus area in the basal surface of the temporal and occipital lobe.
Developmental face blindness may have a genetic basis, as it commonly runs in families and can be present in multiple family members. However, the exact genes that control facial recognition have not yet been identified. Notably, monozygotic twins (i.e., identical twins) have similar face recognition skills, whereas dizygotic twins (i.e., fraternal twins), demonstrate different facial recognition abilities. Interestingly, developmental prosopagnosia appears to present more frequently in individuals with autism spectrum disorder, even though these conditions are independent of one another.
Acquired face blindness, however, often results from severe brain injury to the temporal lobe, particularly the fusiform gyrus. Various types of brain injury -- including
head trauma, inadequate blood supply to the brain (e.g.,
stroke), and inflammation of the brain (e.g.,
encephalitis) -- can suddenly cause problems with facial recognition. In addition, acquired face blindness can result from brain lesions, such as tumors. Finally, brain degenerating diseases, such as
Alzheimer's disease, can also cause acquired face blindness, as they gradually reduce the
size and abilities of parts of the brain.