Developmental milestones (childhood): Clinical sciences

Last updated: June 20, 2025

Developmental milestones (childhood): Clinical sciences

G3n3tics to add

G3n3tics to add

Legg-Calve-Perthes disease
1p36 deletion syndrome: Year of the Zebra
Cleidocranial dysplasia
Developmental dysplasia of the hip: Clinical sciences
Collagen disorders: Pathology review
Approach to connective tissue disorders: Clinical sciences
Fetal alcohol syndrome
Rett syndrome
Approach to a child with Down syndrome (trisomy 21): Clinical sciences
Approach to aneuploidies and microdeletions: Clinical sciences
Approach to inborn errors of metabolism (acute): Clinical sciences
Approach to inborn errors of metabolism (progressive or chronic): Clinical sciences
Approach to neurocutaneous syndromes: Clinical sciences
Approach to prenatal teratogen exposure: Clinical sciences
Approach to primary immunodeficiencies: Clinical sciences
Cystic fibrosis and primary ciliary dyskinesia: Clinical sciences
Sickle cell disease: Clinical sciences
Developmental milestones (newborn and infant): Clinical sciences
Developmental milestones (toddler): Clinical sciences
Developmental milestones (childhood): Clinical sciences
Approach to atypical genitalia: Clinical sciences
Approach to delay or regression in developmental milestones: Clinical sciences
Approach to delayed puberty: Clinical sciences
Approach to feeding and eating disorders: Clinical sciences
Approach to growth faltering: Clinical sciences
Approach to hypotonia (newborn and infant): Clinical sciences
Approach to neurodevelopmental disorders: Clinical sciences
Approach to poor feeding (newborn and infant): Clinical sciences
Approach to precocious puberty: Clinical sciences
Approach to primary amenorrhea: Clinical sciences
Approach to short stature: Clinical sciences
Obesity (pediatrics): Clinical sciences
Congenital cytomegalovirus (NORD)
Chiari malformation
Seizures and epilepsy
Approach to epilepsy: Clinical sciences
Febrile seizure (pediatrics): Clinical sciences
Early infantile epileptic encephalopathy (NORD)
Spinocerebellar ataxia (NORD)
Sturge-Weber syndrome
Spina bifida
Von Hippel-Lindau disease: Year of the Zebra 2024
Neurocutaneous disorders: Pathology review
Human development days 1-4
Human development days 4-7
Human development week 2
Human development week 3
Development of the digestive system and body cavities
Development of the fetal membranes
Development of the placenta
Development of the umbilical cord
Development of twins
Hedgehog signaling pathway
Ectoderm
Endoderm
Mesoderm
Development of the cardiovascular system
Fetal circulation
Development of the eye
Development of the gastrointestinal system
Development of the teeth
Development of the tongue
Development of the axial skeleton
Development of the limbs
Development of the muscular system
Development of the renal system
Development of the reproductive system
Development of the respiratory system
Peutz-Jeghers syndrome
Autism spectrum disorder
Autism spectrum disorder: Clinical sciences
Developmental and learning disorders: Pathology review
Learning disability
von Hippel-Lindau disease
Muscular dystrophies and mitochondrial myopathies: Pathology review
Fatty acid oxidation
Fatty acid synthesis
Classical homocystinuria (NORD)
Homocystinuria
Alkaptonuria
Cystinuria (NORD)
Hartnup disease
Maple syrup urine disease
Ornithine transcarbamylase deficiency
Phenylketonuria (NORD)
Essential fructosuria
Galactosemia
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Hereditary fructose intolerance
Lactose intolerance
Pyruvate dehydrogenase deficiency
Abetalipoproteinemia
Familial hypercholesterolemia
Hyperlipidemia
Hypertriglyceridemia
Glycogen storage disease type I
Glycogen storage disease type II (NORD)
Glycogen storage disease type III
Glycogen storage disease type IV
Glycogen storage disease type V
Mucopolysaccharide storage disease type 1 (Hurler syndrome) (NORD)
Mucopolysaccharide storage disease type 2 (Hunter syndrome) (NORD)
Fabry disease (NORD)
Gaucher disease (NORD)
Krabbe disease
Leukodystrophy
Metachromatic leukodystrophy (NORD)
Niemann-Pick disease type C
Niemann-Pick disease types A and B (NORD)
Tay-Sachs disease (NORD)
Cystinosis
Disorders of amino acid metabolism: Pathology review
Disorders of carbohydrate metabolism: Pathology review
Disorders of fatty acid metabolism: Pathology review
Dyslipidemias: Pathology review
Glycogen storage disorders: Pathology review
Lysosomal storage disorders: Pathology review
Hypothyroidism: Pathology review
Hypothyroidism
Approach to hypothyroidism: Clinical sciences
Hypothyroidism medications
Hyperthyroidism medications
Approach to hyperthyroidism and thyrotoxicosis: Clinical sciences
Hyperthyroidism
Hyperthyroidism: Pathology review
Hashimoto thyroiditis: Clinical sciences
Thyroid nodules: Clinical sciences
Multiple endocrine neoplasia: Pathology review
Disorders of sex chromosomes: Pathology review
Disorders of sexual development and sex hormones: Pathology review
Hypopituitarism: Pathology review
Growth hormone deficiency
Congenital adrenal hyperplasia
Atrial septal defect
Coarctation of the aorta
Patent ductus arteriosus
Ventricular septal defect
Hypoplastic left heart syndrome
Tetralogy of Fallot
Total anomalous pulmonary venous return
Transposition of the great vessels
Persistent truncus arteriosus
Cyanotic congenital heart defects: Pathology review
Acyanotic congenital heart defects: Pathology review
Congenital renal disorders: Pathology review
Congenital gastrointestinal disorders: Pathology review
Congenital neurological disorders: Pathology review
Congenital TORCH infections: Pathology review
Approach to congenital heart diseases (cyanotic): Clinical sciences
Approach to congenital heart diseases (acyanotic): Clinical sciences
Introduction to the immune system
MHC class I and MHC class II molecules
VDJ rearrangement
Antibody classes
Ataxia-telangiectasia
DiGeorge syndrome
Wiskott-Aldrich syndrome
X-linked agammaglobulinemia
Selective immunoglobulin A deficiency
Isolated primary immunoglobulin M deficiency
Adenosine deaminase deficiency
Hyper IgM syndrome
Complement deficiency
Chronic granulomatous disease
Leukocyte adhesion deficiency
Thymic aplasia
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
Cornelia de Lange syndrome: Year of the Zebra
Alagille syndrome (NORD): Year of the Zebra
Alkaptonuria: Year of the Zebra
Alpha-1 antitrypsin deficiency: Year of the Zebra 2024
Chopra-Amiel-Gordon syndrome: Year of the Zebra 2024
FOXG1 syndrome: Year of the Zebra
Gaucher disease (NORD): Year of the Zebra
Gorlin syndrome: Year of the Zebra
Leprosy: Year of the Zebra
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: Year of the Zebra
Nail-patella syndrome: Year of the Zebra
PGAP3-congenital disorder of glycosylation: Year of the Zebra
Phenylketonuria (NORD): Year of the Zebra
Pierre Robin sequence: Year of the Zebra
Retroperitoneal fibrosis: Year of the Zebra
Sanfilippo syndrome: Year of the Zebra
Shwachman-Diamond syndrome: Year of the Zebra
Turner syndrome: Year of the Zebra
Andersen-Tawil syndrome: Year of the Zebra 2025
Peroxisomal disorders: Pathology review
Cytoskeleton and elastin disorders: Pathology review
Epidermolysis bullosa: Year of the Zebra
Gorlin syndrome (Gorlin Syndrome Alliance)
Antepartum care (first trimester): Clinical sciences
Antepartum care (second trimester): Clinical sciences
Antepartum care (third trimester): Clinical sciences
Fetal aneuploidy screening: Clinical sciences
Intrapartum care (1st, 2nd, 3rd, and 4th stages): Clinical sciences
Cystic fibrosis: Pathology review
Autosomal trisomies: Pathology review
Miscellaneous genetic disorders: Pathology review
Gastroschisis
Omphalocele
Approach to abdominal wall defects: Clinical sciences
Early pregnancy loss: Clinical sciences
Pyloric stenosis: Clinical sciences
Pyloric stenosis
Esophageal atresia and tracheoesophageal fistula: Year of the Zebra
Intestinal atresia
Hirschsprung disease
Hirschsprung disease: Year of the Zebra
Alagille syndrome (NORD)
Renal agenesis
Bladder exstrophy
Horseshoe kidney
Hypospadias and epispadias
Potter sequence
Posterior urethral valves
Renal tubular acidosis
Parathyroid disorders and calcium imbalance: Pathology review
Diabetes insipidus
Diabetes insipidus: Clinical sciences
Breast cancer: Pathology review
Breast cancer
Breast cancer screening: Clinical sciences
Colorectal polyps and cancer: Pathology review
Neuroendocrine tumors of the gastrointestinal system: Pathology review
Familial adenomatous polyposis
Multiple endocrine neoplasia: Clinical sciences
Fanconi anemia: Year of the Zebra 2025
Desmoid Tumor (NORD)
Multiple endocrine neoplasia
Oncogenes and tumor suppressor genes
Necrosis and apoptosis
Charcot-Marie-Tooth disease
Spinal muscular atrophy
Precocious puberty
Delayed puberty
5-alpha-reductase deficiency
Androgen insensitivity syndrome
Kallmann syndrome
Puberty and Tanner staging
Amenorrhea
Hydronephrosis
Beta-thalassemia: Year of the Zebra
Alpha-thalassemia
Beta-thalassemia
Von Willebrand disease
Protein S deficiency
Factor V Leiden
Protein C deficiency
Antithrombin III deficiency
Zellweger spectrum disorders (NORD)
Glycogen metabolism
Hemochromatosis: Clinical sciences
Lesch-Nyhan syndrome
Purine and pyrimidine synthesis and metabolism disorders: Pathology review
Adrenoleukodystrophy (NORD)
Alzheimer disease: Clinical sciences
Alzheimer disease

Decision-Making Tree

Transcript

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Developmental milestones are behaviors and functional skills that children are expected to acquire by a specific age. These milestones are typically achieved in a predictable sequence and are divided into five major categories: gross motor development, which relates to the movement of large muscles; fine motor development, which relates to the movement of small muscles; cognitive development, which includes reasoning, memory, and problem-solving; social-emotional development, which describes attachment to and interactions with others; and finally, language development, which consists of receptive and expressive communication.

Your overall goal is to assess the child’s developmental milestones according to their age, using the caregiver’s report as well as direct observation. Understanding normal developmental milestones will help you recognize when a child is at risk for a developmental delay that would benefit from a more detailed evaluation and early intervention services.

Now, when a pediatric patient presents for assessment of their developmental milestones, first, obtain a focused history and physical exam. During the history, be sure to review birth history, including gestational age and birth weight, as both prematurity and low birth weight are associated with developmental delays.

Also ask about family history of developmental delays, as some developmental disorders such as autism spectrum disorder have a genetic component. You should also take an interval history to determine what new skills the child has learned since the last clinic visit.

Additionally, observe the interactions between the child and their caregiver, and ask the caregiver if they have any concerns about their child’s development.

Now, here’s a clinical pearl to keep in mind! Caregivers spend the most time with their child and are often the first to notice when something isn’t quite right. Whenever a caregiver is concerned about their child’s development, be sure to investigate further!

When it comes to the physical exam, check reflexes, assess muscle tone, and test their balance. Additionally, use this time to observe how the child interacts with the world, with their caregiver, and with you, as this can help you gauge the child’s development.

Once you are done with history and physical exam findings, it’s time to assess developmental milestones, based on the child’s age. Let’s start by discussing expected milestones for a three- year-old. By this age, the child has achieved new gross motor skills, including the ability to walk up stairs with alternating feet and without using a handrail. A three-year-old can also balance on one leg, walk heel-to-toe when asked, pedal a tricycle, and catch a ball. Fine motor skills are more advanced, and now they are able to draw circles and crosses, and can string small items together, like beads or macaroni.

Cognitive skills have become more advanced, and the child now can eat independently, and are toilet trained. They can also put on their own shoes, match letters and numbers, and understand comparisons, like long versus short, or hot versus cold. From a social-emotional standpoint, they now know their gender and their age, and they can point to themselves in pictures, take turns with others, and enjoy imaginative play. Language milestones include the ability to use a vocabulary of over 200 words, make three-word sentences, and use plurals. The three-year-old child is also known for asking all the “W” questions, like who, what, when, where, and why. To strangers, about 75% of their speech is now intelligible.

While you assess your patient for their developmental milestones, keep an eye out for age-specific red flags that may signal a developmental delay. Some red flags to look for in a three-year-old include difficulty using stairs, inability to form three-word sentences, and lack of pretend play.

Alright, now let’s move on to the milestones of a four-year-old! By this age, the child has achieved several more gross motor milestones, which include hopping on one foot and galloping. Fine motor skills are more advanced, and now the child can hold a pencil properly, draw squares and “X” shapes, write letters, and tie a knot.

A four-year-old has the cognitive skills required to brush their teeth, wash their hands independently, and use a fork. They now know their colors and can count to four. They can also understand analogies, such as, banana is to fruit as broccoli is to vegetable. Social-emotional development now means that the four-year-old has a favorite friend and enjoys group play. Additionally, they are now able to label emotions and are aware of the concept of deception, so they might lie to avoid getting in trouble. Newly acquired language skills include the ability to follow three-step directions and tell stories. A four-year-old uses a vocabulary of 300 to 1000 words, and to a stranger, their speech should be 100% intelligible.

Sources

  1. "CDC’s Developmental Milestones. " Centers for Disease Control and Prevention. (24 Sept. 2018. Last reviewed 2023)
  2. "Developmental Milestones [published correction appears in Pediatr Rev. 2016 Jun;37(6):266]." Pediatr Rev. (2016;37(1):25-47. )
  3. "Nelson Textbook of Pediatrics. 21st ed. " Elsevier (2020. )
  4. "School Readiness. " Pediatr Rev. (2016; 37 (11): 501–503.)