Paracetamol toxicity


Paracetamol toxicity


0 / 8 complete

USMLE® Step 1 questions

0 / 2 complete

High Yield Notes

15 pages


Paracetamol toxicity

of complete


USMLE® Step 1 style questions USMLE

of complete

A 16-year-old boy is brought to the emergency department for evaluation of severe abdominal pain,  nausea, and vomiting. The pain started three hours ago and has been increasing in severity. The patient admits to swallowing 30 pills of acetaminophen in an attempt to end his life. Temperature is 37.9 C° (100.2 F°), respirations are 15/minute, pulse is 92/minute, and blood pressure is 120/80 mmHg.  On physical examination, right upper quadrant tenderness is noted. Which of the following best describes the pathophysiologic process underlying this medication toxicity? 

External References

First Aid


External Links


Paracetamol toxicity, also known as acetaminophen toxicity, is caused by excessive use or overdose of the analgesic drug paracetamol, also known as acetaminophen in North America. Paracetamol toxicity can lead to liver damage and, in severe cases, liver failure.

People with paracetamol toxicity present with nausea, vomiting, abdominal pain, and jaundice. Treatment may involve administering N-acetylcysteine within 8 hours of the ingestion. It can also involve hemodialysis and liver transplant in case of severe liver damage.


Copyright © 2023 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.