Sleep apnea

Sleep apnea

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Record

Familial hypercholesterolemia
Hypertriglyceridemia
Atrioventricular nodal reentrant tachycardia (AVNRT)
Primary adrenal insufficiency
Thyroid eye disease (NORD)
Autoimmune polyglandular syndrome type 1 (NORD)
Opsoclonus myoclonus syndrome (NORD)
Acoustic neuroma (schwannoma)
Nasal polyps
Sleep apnea
Retropharyngeal and peritonsillar abscesses
Esophageal cancer
Gastroesophageal reflux disease (GERD)
Laryngomalacia
Laryngitis
Bacterial epiglottitis
Short bowel syndrome (NORD)
Abdominal hernias
Portal hypertension
Alpha 1-antitrypsin deficiency
Alpha-thalassemia
Beta-thalassemia
Iron deficiency anemia
Sideroblastic anemia
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Autoimmune hemolytic anemia
Sickle cell disease (NORD)
Anemia of chronic disease
Folate (Vitamin B9) deficiency
Vitamin B12 deficiency
Acute intermittent porphyria
Thrombotic thrombocytopenic purpura
Von Willebrand disease
Heparin-induced thrombocytopenia
Antithrombin III deficiency
Factor V Leiden
Protein C deficiency
Protein S deficiency
Myelodysplastic syndromes
Polycythemia vera (NORD)
Myelofibrosis (NORD)
Essential thrombocythemia (NORD)
Langerhans cell histiocytosis
Waldenstrom macroglobulinemia
Abscesses
Cytomegalovirus infection after transplant (NORD)
Vitiligo
Coxsackievirus
Human herpesvirus 6 (Roseola)
Parvovirus B19
Human herpesvirus 8 (Kaposi sarcoma)
Developmental dysplasia of the hip
Klumpke paralysis
Meniscus tear
Compartment syndrome
Osteoporosis
Osteomalacia and rickets
Lordosis, kyphosis, and scoliosis
Scleroderma
Spinocerebellar ataxia (NORD)
Early infantile epileptic encephalopathy (NORD)
von Hippel-Lindau disease
Focal segmental glomerulosclerosis (NORD)
Endometritis
Pelvic inflammatory disease
Congenital cytomegalovirus (NORD)
Sinusitis
Congenital pulmonary airway malformation
Chronic bronchitis
Idiopathic pulmonary fibrosis
Pancoast tumor
Mesothelioma

Flashcards

Sleep apnea

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Sleep apnea is a sleep disorder which causes irregular breathing and snoring patterns that can ultimately cause apnea, which is where a person momentarily stops breathing altogether. The inability to get restful sleep can also lead to severe exhaustion.

Individuals can have obstructive sleep apnea, central sleep apnea, or features of both. Obstructive sleep apnea is the most common form, and it develops when there’s a blockage of the airways. Now, air has to go from the nose through the nasopharynx into the laryngopharynx, through the larynx and then into the trachea. Somewhere along that path, there might be a blockage in the flow of air.

Allergies might cause swelling in the tissues in the nasopharynx, or there might be swollen adenoid glands or tonsils because of an infection. There might be a severe overbite which pulls the jaw back and blocks the airway. In individuals that are overweight, there could be too much weight in the soft tissues of the neck, which can weigh down the airway especially when a person is lying down.

These problems are most obvious at night because hormonal changes at night cause the muscles around the airway to become slightly less stiff while sleeping. This means that they are less able to keep the airway open, making it more likely to get a bit squashed or obstructed.

Central sleep apnea, on the other hand, refers to the fact that the problem is “central” or related to the central nervous system. This is where the brain intermittently stops making an effort to breathe for 10 to 30 seconds. The apnea can persist for several seconds even after waking up, triggering feelings of panic and further disrupting the sleep cycle.

Central sleep apnea starts with an initial episode of hyperpnea, which is when the brain directs the lungs to start hyperventilating during sleep by increasing the respiratory rate. This rapid breathing causes hypocapnia, a drop in the blood’s carbon dioxide levels.

When the carbon dioxide falls below a certain threshold, the body slips into a state of apnea, making no effort to breathe and taking in no oxygen. This causes the carbon dioxide levels to rise back to normal levels and then, as the apnea persists, they keep rising to a point which is called hypercapnia. The really high carbon dioxide levels trigger hyperpnea again, and the cycle starts all over. Essentially, the respiratory system is going rapidly back and forth between two states, first making no effort to breathe and then hyperventilating, with no in-between.

Key Takeaways

Sleep apnea is a sleep disorder characterized by brief interruptions of breathing during sleep. These apneic events can occur several times an hour and last from a few seconds to minutes. Symptoms include snoring, daytime sleepiness and fatigue, and morning headaches. There are two main types of sleep apnea: obstructive sleep apnea, caused by a physical blockage of the airway, and central sleep apnea, caused by a failure of the brain to properly control breathing. Older age, obesity, and male sex are the strongest risk factors.

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "CURRENT Medical Diagnosis and Treatment 2020" McGraw Hill Professional (2019)
  5. "Meta-analysis: Continuous Positive Airway Pressure Improves Insulin Resistance in Patients with Sleep Apnea without Diabetes" Annals of the American Thoracic Society (2013)
  6. "Obstructive sleep apnoea syndrome and its management" Therapeutic Advances in Chronic Disease (2015)
  7. "Sleep Pathologies in Depression and the Clinical Utility of Polysomnography" The Canadian Journal of Psychiatry (2010)