USMLE® Step 1 style questions USMLE
A researcher is studying the histology of the spleen and the different types of cells and structures found in it. A biopsy is taken from a spleen and is examined under a microscope, as shown below. Which of the following best describes area A?
Lymphoid tissue and organs contain a lot of lymphocytes and other white blood cells.
The primary lymphoid organs include the thymus and bone marrow.
The spleen is the largest lymphoid organ.
It receives blood from the splenic artery and is the only lymphoid organ that primarily filters blood instead of lymph.
It’s an encapsulated organ that’s typically about 12 cm in length, 7 cm wide, and 3 cm deep.
Although, when looking at the spleen histologically after it’s been stained with H&E, the red pulp is actually stained a combination of pink and purple; and the white pulp is stained dark purple because it contains a large number of basophilic nuclei.
The connective tissue also forms short extensions into the spleen called trabeculae.
These trabecular arteries are branches of the splenic artery.
The remainder of the tissue seen in this image is the highly vascular red pulp.
Now, if we move to a different region of the spleen, we can see there are areas that are more basophilic and stain mainly purple.
The trabecular arteries from the previous image branch even more and become central arterioles.