Test precision and accuracy

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Test precision and accuracy

Semester 1

Semester 1

Introduction to the skeletal system
Introduction to the muscular system
Anatomical terminology
Anatomy of the breast
Muscles of the thoracic wall
Anatomy clinical correlates: Breast
Introduction to the cranial nerves
Cranial nerve pathways
Anatomy of the thyroid and parathyroid glands
Anatomy of the pelvic girdle
Bones of the vertebral column
Joints of the vertebral column
Muscles of the back
Vessels and nerves of the vertebral column
Anatomy clinical correlates: Bones, joints and muscles of the back
Anatomy clinical correlates: Vertebral canal
Bones of the lower limb
Fascia, vessels and nerves of the lower limb
Anatomy of the anterior and medial thigh
Muscles of the gluteal region and posterior thigh
Vessels and nerves of the gluteal region and posterior thigh
Anatomy of the popliteal fossa
Anatomy of the leg
Anatomy of the foot
Anatomy of the hip joint
Anatomy of the knee joint
Anatomy of the tibiofibular joints
Joints of the ankle and foot
Bones of the upper limb
Fascia, vessels and nerves of the upper limb
Anatomy of the brachial plexus
Anatomy of the pectoral and scapular regions
Anatomy of the arm
Muscles of the forearm
Vessels and nerves of the forearm
Muscles of the hand
Anatomy of the sternoclavicular and acromioclavicular joints
Anatomy of the glenohumeral joint
Anatomy of the elbow joint
Anatomy of the radioulnar joints
Joints of the wrist and hand
Anatomy clinical correlates: Clavicle and shoulder
Anatomy clinical correlates: Axilla
Anatomy clinical correlates: Arm, elbow and forearm
Anatomy clinical correlates: Wrist and hand
Anatomy clinical correlates: Median, ulnar and radial nerves
Suicide
Alcohol use disorder
Glycolysis
Citric acid cycle
Electron transport chain and oxidative phosphorylation
Gluconeogenesis
Glycogen metabolism
Pentose phosphate pathway
Physiological changes during exercise
Amino acid metabolism
Nitrogen and urea cycle
Fatty acid synthesis
Fatty acid oxidation
Ketone body metabolism
Cholesterol metabolism
Pyruvate dehydrogenase deficiency
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Carbohydrates and sugars
Glycogen storage disease type I
Glycogen storage disease type III
Phenylketonuria (NORD)
Familial hypercholesterolemia
Hypertriglyceridemia
Glycogen storage disorders: Pathology review
Introduction to biostatistics
Probability
Types of data
Hypothesis testing: One-tailed and two-tailed tests
Type I and type II errors
Sensitivity and specificity
Test precision and accuracy
Positive and negative predictive value
Cellular structure and function
Cell membrane
Selective permeability of the cell membrane
Extracellular matrix
Cell-cell junctions
Endocytosis and exocytosis
Osmosis
Resting membrane potential
Nernst equation
Cytoskeleton and intracellular motility
Cell signaling pathways
Zellweger spectrum disorders (NORD)
Adrenoleukodystrophy (NORD)
Ehlers-Danlos syndrome
Osteogenesis imperfecta
Marfan syndrome
Nuclear structure
Transcription of DNA
Gene regulation
Amino acids and protein folding
DNA structure
Translation of mRNA
Epigenetics
Protein structure and synthesis
DNA replication
Nucleotide metabolism
Lac operon
DNA damage and repair
Mitosis and meiosis
Cell cycle
DNA mutations
Adenosine deaminase deficiency
Xeroderma pigmentosum
Purine and pyrimidine synthesis and metabolism disorders: Pathology review
Polymerase chain reaction (PCR) and reverse-transcriptase PCR (RT-PCR)
ELISA (Enzyme-linked immunosorbent assay)
DNA cloning
Gel electrophoresis and genetic testing
Karyotyping
Fluorescence in situ hybridization
Human development days 1-4
Human development days 4-7
Human development week 2
Human development week 3
Ectoderm
Mesoderm
Endoderm
Development of the placenta
Development of the fetal membranes
Hedgehog signaling pathway
Development of the umbilical cord
Development of the axial skeleton
Development of the limbs
Development of the muscular system
Hardy-Weinberg equilibrium
Mendelian genetics and punnett squares
Inheritance patterns
Independent assortment of genes and linkage
Evolution and natural selection
Down syndrome (Trisomy 21)
Edwards syndrome (Trisomy 18)
Patau syndrome (Trisomy 13)
Huntington disease
Turner syndrome
Klinefelter syndrome
Cri du chat syndrome
Achondroplasia
Hereditary spherocytosis
Albinism
Cystic fibrosis
Hemochromatosis
Primary ciliary dyskinesia
Alpha-thalassemia
Beta-thalassemia
Sickle cell disease (NORD)
Hemophilia
Muscular dystrophy
Mitochondrial myopathy
Autosomal trisomies: Pathology review
Muscular dystrophies and mitochondrial myopathies: Pathology review
Miscellaneous genetic disorders: Pathology review
Light microscopy and staining methods
Pituitary gland histology
Thyroid and parathyroid gland histology
Adrenal gland histology
Liver histology
Blood histology
Thymus histology
Spleen histology
Lymph node histology
Skin histology
Bone histology
Skeletal muscle histology
Cartilage histology
Central nervous system histology
Peripheral nervous system histology
Mammary gland histology
Bacterial structure and functions
Viral structure and functions
Pediculus humanus and Phthirus pubis (Lice)
Sarcoptes scabiei (Scabies)
Free radicals and cellular injury
Ischemia
Necrosis and apoptosis
Hypoxia
Amyloidosis
Inflammation
Wound healing
Atrophy, aplasia, and hypoplasia
Hyperplasia and hypertrophy
Metaplasia and dysplasia
Oncogenes and tumor suppressor genes
Conn syndrome
Cushing syndrome
Congenital adrenal hyperplasia
Primary adrenal insufficiency
Hyperaldosteronism
Adrenal cortical carcinoma
Hyperthyroidism
Graves disease
Thyroid storm
Hypothyroidism
Thyroid cancer
Hyperparathyroidism
Hypercalcemia
Hypoparathyroidism
Hypocalcemia
Diabetes mellitus
Hyperpituitarism
Pituitary adenoma
Hyperprolactinemia
Prolactinoma
Gigantism
Acromegaly
Hypopituitarism
Hypoprolactinemia
Diabetes insipidus
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Androgen insensitivity syndrome
5-alpha-reductase deficiency
Thyroid nodules and thyroid cancer: Pathology review
Parathyroid disorders and calcium imbalance: Pathology review
Jaundice
Non-alcoholic fatty liver disease
Viral hepatitis
Iron deficiency anemia
Sideroblastic anemia
Anemia of chronic disease
Hemolytic disease of the newborn
Autoimmune hemolytic anemia
Pyruvate kinase deficiency
Aplastic anemia
Megaloblastic anemia
Folate (Vitamin B9) deficiency
Vitamin B12 deficiency
Vitamin K deficiency
Von Willebrand disease
Antithrombin III deficiency
Factor V Leiden
Chronic leukemia
Acute leukemia
Leukemoid reaction
Langerhans cell histiocytosis
Sepsis

Transcript

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Let’s say you want to figure out if eating more daily servings of vegetables will decrease a person’s body mass index (BMI), which is a number calculated by dividing a person’s weight in kilograms by their height in meters squared.

The first step to figuring this out is to collect data about each person in the study, and this is typically done using some type of measurement tool.

For example, we might use a scale to measure a person’s weight, a measuring rod to measure a person’s height, and design a survey to find out how many daily servings of vegetables a person eats.

Now, it’s important to collect high quality data in a study, which means the information collected in the study should accurately reflect what’s really happening.

For example, if a person eats 5 servings of vegetables per day, the data should reflect that they eat 5 servings, instead of 2 servings.

Data quality is determined by the tools used to collect the information, and ideally, these tools have high validity - or accuracy - and high reliability - or repeatability.

A tool with high validity will provide a measurement that’s very close to the true or known value for the thing being measured.

Let’s say we’re going to measure a woman’s weight using two different scales.

One scale is a family heirloom that was passed down over multiple generations - so it’s pretty old - and the other scale was a gift from your friend who’s a doctor - so it’s really modern and sophisticated.

The old scale provides a measurement of 80 kilograms, and the modern scale provides a very different measurement of 66 kilograms.

In reality, this woman weighs 65 kilograms, so, since the modern scale provides a measurement that is closer to the woman’s true weight, the modern scale has higher validity.

Using tools with high validity is important for getting correct results in descriptive or inferential statistics.

For example, if we used the old scale for all the people in the group with hypertension, but used the new scale for the people in the group without hypertension, then we would think the group with hypertension has a much higher mean body mass index than they really do.

This would lead to an overestimation of the association between body mass index and hypertension.

On the other hand, a tool with high reliability will consistently get the same results, no matter how many times the measurement is repeated.

So, let’s say you measure each person’s weight 3 times in a row on each scale.

On the old scale, the 3 measurements are 80 kilograms, 81 kilograms, and 80 kilograms, and on the modern scale, the 3 measurements are 66 kilograms, 75 kilograms, and 60 kilograms.

Now, even though the modern scale has higher validity, it actually has lower reliability, because the results of the 3 tests were not consistent with each other.

Key Takeaways

In testing and measurement, accuracy and precision are two important concepts of the quality of the test results. Accuracy refers to how close the measured value is to the true value. In other words, it reflects the degree to which a test result is correct or exact. A test can be accurate if it uses a tool with high validity.

Precision, on the other hand, refers to the consistency or reproducibility of the results obtained from a test. It reflects the degree of variation or uncertainty in the results. A precise test uses tools with high reliability.

So, a tool with high validity will get results that are close to the true value, and a tool with high reliability will get results that are consistent no matter how many times the measurement is repeated.