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A complement deficiency is a condition in which the body doesn't have enough of the proteins called complements, which work together to fight infection. Complement deficiencies can be inherited or acquired. Inherited complement deficiencies are caused by a change (mutation) in the gene that codes for one of the proteins in the complement system. Acquired complement deficiencies can be caused by infections, cancer, and autoimmune diseases such as lupus. People with an inherited or acquired complement deficiency are at risk of severe infections, including meningitis, sepsis, and pneumonia.
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