Video - Narcolepsy (NORD)

Narcolepsy is a sleep disorder that involves a decrease in the production of the neurotransmitter orexin (hypocretin) in the lateral hypothalamus. It is characterized by chronic excessive daytime sleepiness, often with a sudden loss of muscle tone (cataplexy). Other symptoms include sleep paralysis and hypnagogic and hypnopompic hallucinations.

Narcolepsy can have a significant impact on a person's quality of life, as it can interfere with work, school, and social activities. Diagnosis is by polysomnography and multiple sleep latency testing. It is often treated with a combination of lifestyle changes, such as establishing a regular sleep schedule and avoiding caffeine and alcohol; and medications such as modafinil, amphetamines, and antidepressants.