Video - Pancreas histology

The pancreas is an abdominal gland that has both exocrine and endocrine functions. Its exocrine part produces digestive enzymes in the small intestine, while its endocrine part produces hormones such as insulin and glucagon that regulate the body's blood sugar levels. Histologically, three main types of tissue make the pancreas: acinar cells, duct cells, and islet cells. Acinar cells produce enzymes and are secreted into the small intestine to aid digestion.

Duct cells line the pancreatic ducts and secrete a bicarbonate-rich fluid to neutralize stomach acid as it enters the small intestine. Islets of Langerhans produce hormones such as insulin and glucagon. In addition to these three main types of cells, the pancreas also contains supportive stromal cells and blood vessels. The stroma of the pancreas is composed of connective tissue that provides support, blood vessels, and nerve fibers.