Acute intermittent porphyria
Acute intermittent porphyria is a rare autosomal dominant metabolic disorder affecting the production of heme. It is characterized by a deficiency of the enzyme porphobilinogen deaminase. Acute intermittent porphyria one of the three types of acute porphyria, and is the second most common form of porphyria overall (porphyria cutanea tarda being the most common). Severe and poorly localized abdominal pain is a very common symptom. Other symptoms include port-wine colored urine, polyneuropathy, psychological disturbances, precipitation by drugs (cytochrome P-450 inducers), alcohol, and starvation. Treatment consists of glucose and heme, which inhibit ALA synthase.