Reviewed by Rishi Desai, MD, MPH
Body fluid compartments
On average, the body is comprised of approximately 60% water at any given time. This varies depending on gender and body composition, as adipose tissue contains less water than skeletal muscle and, in general, females typically have a higher percentage of adipose tissue when compared to males. Of this 60% water, approximately two-thirds is contained within cells in the intracellular fluid compartment. The remaining one-third is distributed in the extracellular fluid compartment which includes plasma fluid and interstitial fluid. This distribution is important because when solute concentrations are altered there can be a shift of water between fluid compartments leading to various clinical symptoms like edema.