ECG basics

Last updated: June 19, 2025

ECG basics

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Congenital heart defects: Clinical
Acyanotic congenital heart defects: Pathology review
Hypoplastic left heart syndrome
Congenital syphilis
Congenital pulmonary airway malformation
Congenital diaphragmatic hernia
Pulmonary hypertension
Development of the respiratory system
Development of the gastrointestinal system
Development of the cardiovascular system
Development of the nervous system
Disorders of carbohydrate metabolism: Pathology review
Newborn management: Clinical
Neonatal ICU conditions: Clinical
Congenital TORCH infections: Pathology review
Perinatal infections: Clinical
Congenital disorders: Clinical
Autosomal trisomies: Pathology review
Miscellaneous genetic disorders: Pathology review
Disorders of amino acid metabolism: Pathology review
Disorders of fatty acid metabolism: Pathology review
Glycogen storage disorders: Pathology review
Lysosomal storage disorders: Pathology review
Respiratory distress syndrome: Pathology review
Hypoxia
Necrosis and apoptosis
Ischemia
Lung volumes and capacities
Clinical Skills: Mechanical ventilation - conventional ventilators
Respiratory system anatomy and physiology
Reading a chest X-ray
Anatomic and physiologic dead space
Alveolar surface tension and surfactant
Compliance of lungs and chest wall
Combined pressure-volume curves for the lung and chest wall
Ventilation
Zones of pulmonary blood flow
Regulation of pulmonary blood flow
Pulmonary shunts
Ventilation-perfusion ratios and V/Q mismatch
Breathing cycle
Airflow, pressure, and resistance
Ideal (general) gas law
Boyle's law
Dalton's law
Henry's law
Graham's law
Gas exchange in the lungs, blood and tissues
Diffusion-limited and perfusion-limited gas exchange
Alveolar gas equation
Oxygen binding capacity and oxygen content
Oxygen-hemoglobin dissociation curve
Carbon dioxide transport in blood
Breathing control
Pulmonary chemoreceptors and mechanoreceptors
Pulmonary changes at high altitude and altitude sickness
Pulmonary changes during exercise
Sensitivity and specificity
Positive and negative predictive value
Test precision and accuracy
Incidence and prevalence
Relative and absolute risk
Odds ratio
Attributable risk (AR)
Mortality rates and case-fatality
Dilated cardiomyopathy
Restrictive cardiomyopathy
Hypertrophic cardiomyopathy
Persistent truncus arteriosus
Transposition of the great vessels
Total anomalous pulmonary venous return
Tetralogy of Fallot
Patent ductus arteriosus
Coarctation of the aorta
Atrial septal defect
ECG basics
ECG axis
ECG rate and rhythm
ECG intervals
Osteomalacia and rickets
Hemolytic disease of the newborn
Transient tachypnea of the newborn
Complications during pregnancy: Pathology review
Hypertensive disorders of pregnancy: Clinical
Jaundice
Jaundice: Pathology review
Jaundice: Clinical
Beta-thalassemia
Neonatal hepatitis
Congenital cytomegalovirus (NORD)
Primary biliary cholangitis
Biliary atresia
Development of the digestive system and body cavities
Blood histology
Pediatric lower airway conditions: Clinical
Pediatric upper airway conditions: Clinical
Pressure-volume loops
Changes in pressure-volume loops

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An electrocardiogram is also known as an ECG; the Dutch and German version of the word, elektrokardiogram, is shortened to EKG. It is a tool used to visualize, or “gram,” the electricity, or “electro,” that flows through the heart, or “cardio.” Specifically, a 12-lead ECG tracing shows how the depolarization wave, which is a wave of positive charge, moves during each heartbeat, by providing the perspectives of different sets of electrodes. This particular set of electrodes is called lead II; one electrode is placed on the right arm and the other on the left leg. Essentially, when the wave’s moving toward the left leg electrode, you get a positive deflection. This big, positive deflection corresponds to the wave moving down the septum.

To understand the basics, let’s start with an example of how we can look at the heart with only one pair of electrodes: a positive and a negative one. These electrodes detect the charge on the outside of the cell. Remember, at rest, cells are negatively charged relative to the slightly positive outside environment; let’s make these cells red. When they depolarize, the cells become positively charged, and leave a slightly negative charge in the outside environment; let’s make these cells green. Now, if we freeze this “wave of depolarization” as it’s moving through the cells, half of the cells are negative, or depolarized, and half are positive and resting; therefore, there’s a difference of charge across this set of cells. You can think of the charge difference as being a dipole, because there are two electrical poles. We can draw this dipole out as an arrow, or vector, pointing towards the positive charge. Remember, the electrodes detect charge on the outside of the cell, so this points toward where the positive charge is, outside.

Now, if there’s a dipole vector pointing toward the positive electrode, then the ECG tracing shows it as a positive deflection; the bigger the dipole is, the bigger the deflection is. If we unpause this, then everything becomes depolarized. Since there’s no difference in charge, there’s no dipole, and thus no deflection. Moments later, a wave of repolarization goes through, and the cells become negative once again. Pausing halfway through again, now the vector dipole goes in the opposite direction, and faces the negative electrode; this means that there will be a negative ECG tracing. Again, the bigger the dipole is, the bigger the negative deflection is. Even though it’d be nice if the depolarization wave lined up perfectly with the electrodes, usually that’s not the case. So, we simply look at the vector component that is parallel to that electrode. For example, let’s say that the depolarization happened this way, at an angle; then, we’d simply break the vector into two parts. The one we care about is the one that’s going towards the positive electrode, which causes a deflection, even though it’s a slightly smaller deflection than previously. In other words, the size of the deflection on the ECG tracing always corresponds to the magnitude, or size, of the dipole in the direction of the electrode. The perpendicular component isn’t pointing at the electrodes, so it doesn’t cause any deflection. In fact, if there’s a depolarization wave that goes straight up, perpendicular to the positive and negative electrodes, there would be no deflection!

In a standard ECG, there are 10 electrodes: four limb electrodes, with one each on the left arm, right arm, left leg, and right leg; and six precordial electrodes, V1 through V6, that wrap around the chest. The right leg electrode is usually used as a neutral lead. The heart is a three-dimensional organ, so V1 through V6 line up in the transverse, or horizontal, plane of the heart. Each electrode is set up to detect any wave of positive charge coming towards it. These are collectively called the chest leads.

Sources

  1. "Medical Physiology" Elsevier (2016)
  2. "Physiology" Elsevier (2017)
  3. "Human Anatomy & Physiology" Pearson (2017)
  4. "Principles of Anatomy and Physiology" Wiley (2014)
  5. "Screening for Cardiovascular Disease Risk With Electrocardiography" JAMA (2018)
  6. "Screening for Coronary Heart Disease With Electrocardiography: U.S. Preventive Services Task Force Recommendation Statement" Annals of Internal Medicine (2012)
  7. "Activation of the Interventricular Septum" Circulation Research (1955)