Hypertension

Last updated: December 18, 2025

Hypertension

5600

5600

Anatomy of the larynx and trachea
Bones and joints of the thoracic wall
Vessels and nerves of the thoracic wall
Anatomy of the lungs and tracheobronchial tree
Muscles of the thoracic wall
Anatomy of the pleura
Development of the respiratory system
Nasal cavity and larynx histology
Bronchioles and alveoli histology
Trachea and bronchi histology
Respiratory system anatomy and physiology
Ventilation-perfusion ratios and V/Q mismatch
Ventilation
Alveolar surface tension and surfactant
Upper respiratory tract infection
Sinusitis
Retropharyngeal and peritonsillar abscesses
Laryngitis
Bacterial epiglottitis
Anatomy of the pharynx and esophagus
Anatomy of the superior mediastinum
Anatomy of the inferior mediastinum
Regulation of pulmonary blood flow
Zones of pulmonary blood flow
Airflow, pressure, and resistance
Breathing cycle and regulation
Lung volumes and capacities
Pulmonary edema
Anatomic and physiologic dead space
Pulmonary shunts
Diffusion-limited and perfusion-limited gas exchange
Alveolar gas equation
Gas exchange in the lungs, blood and tissues
Anatomy clinical correlates: Thoracic wall
Anatomy clinical correlates: Pleura and lungs
Otitis media
Eustachian tube dysfunction
Corynebacterium diphtheriae (Diphtheria)
Haemophilus influenzae
Bacterial tracheitis
Pediatric upper airway conditions: Clinical
Rhinovirus
Adenovirus
Moraxella catarrhalis
Streptococcus pyogenes (Group A Strep)
Streptococcus pneumoniae
Human parainfluenza viruses
Epstein-Barr virus (Infectious mononucleosis)
Influenza virus
Pediatric ear, nose, and throat conditions: Clinical
Alpha 1-antitrypsin deficiency
Compliance of lungs and chest wall
Combined pressure-volume curves for the lung and chest wall
Breathing cycle
Allergic rhinitis
Nasopharyngeal carcinoma
Oral cancer
Nasal polyps
Warthin tumor
Sjogren syndrome
Nasal, oral and pharyngeal diseases: Pathology review
Choanal atresia
Sialadenitis
Aphthous ulcers
Sleep apnea
Thoracic outlet syndrome
Neonatal respiratory distress syndrome
Cystic fibrosis
Cystic fibrosis: Clinical
Cystic fibrosis: Pathology review
Restrictive lung diseases
Restrictive lung diseases: Pathology review
Idiopathic pulmonary fibrosis
Sarcoidosis
Hypersensitivity pneumonitis
Obstructive lung diseases: Pathology review
Chronic bronchitis
Emphysema
Asthma
Asthma: Clinical
Bronchiectasis
Type I hypersensitivity
Pharmacodynamics: Desensitization and tolerance
Pneumonia: Pathology review
Pneumonia
Pneumonia: Clinical
Mycoplasma pneumoniae
Pulmonary changes at high altitude and altitude sickness
Oxygen-hemoglobin dissociation curve
Bronchodilators: Leukotriene antagonists and methylxanthines
Bronchodilators: Beta 2-agonists and muscarinic antagonists
Mycobacterium tuberculosis (Tuberculosis)
Antituberculosis medications
Tuberculosis: Pathology review
Respiratory syncytial virus
Lung cancer
Lung cancer: Clinical
Lung cancer and mesothelioma: Pathology review
Pancoast tumor
Horner syndrome
Superior vena cava syndrome
Chronic obstructive pulmonary disease (COPD): Clinical
Chlamydia pneumoniae
Coxiella burnetii (Q fever)
Klebsiella pneumoniae
Streptococcus pneumoniae
Pseudomonas aeruginosa
Chronic granulomatous disease
Bordetella pertussis (Whooping cough)
Pleural effusion, pneumothorax, hemothorax and atelectasis: Pathology review
Pleural effusion: Clinical
Pleural effusion
Pneumothorax: Clinical
Pneumothorax
Acute respiratory distress syndrome
Acute respiratory distress syndrome: Clinical
Pulmonary hypertension
Apnea, hypoventilation and pulmonary hypertension: Pathology review
Pulmonary embolism
Pulmonary hypoplasia
Congenital diaphragmatic hernia
Mesothelioma
Respiratory distress syndrome: Pathology review
Pulmonary changes during exercise
Pulmonary chemoreceptors and mechanoreceptors
Pulmonary corticosteroids and mast cell inhibitors
Syncope: Clinical
Anatomy of the heart
Anatomy of the coronary circulation
ECG rate and rhythm
ECG normal sinus rhythm
ECG QRS transition
Cardiac conduction system
Normal heart sounds
Vasculitis: Clinical
Aortic aneurysms and dissections: Clinical
Vascular tumors
Aneurysms
Aortic dissection
Aortic dissections and aneurysms: Pathology review
Raynaud phenomenon
Deep vein thrombosis
Deep vein thrombosis and pulmonary embolism: Pathology review
Thrombophlebitis
Lymphedema
Angiosarcomas
Cardiac and vascular tumors: Pathology review
Sturge-Weber syndrome
Vasculitis: Pathology review
Kawasaki disease
Kawasaki disease: Clinical
Mitral valve disease
Tricuspid valve disease
Aortic valve disease
Pulmonary valve disease
Introduction to the cardiovascular system
Development of the cardiovascular system
Fetal circulation
Cardiac muscle histology
Arteriole, venule and capillary histology
Artery and vein histology
Cardiovascular system anatomy and physiology
Coronary circulation
Lymphatic system anatomy and physiology
Blood pressure, blood flow, and resistance
Laminar flow and Reynolds number
Compliance of blood vessels
Pressures in the cardiovascular system
Resistance to blood flow
Control of blood flow circulation
Microcirculation and Starling forces
Measuring cardiac output (Fick principle)
Frank-Starling relationship
Stroke volume, ejection fraction, and cardiac output
Cardiac afterload
Cardiac preload
Law of Laplace
Cardiac contractility
Cardiac and vascular function curves
Altering cardiac and vascular function curves
Cardiac cycle
Pressure-volume loops
Cardiac work
Changes in pressure-volume loops
Abnormal heart sounds
Action potentials in myocytes
Excitability and refractory periods
Action potentials in pacemaker cells
Cardiac excitation-contraction coupling
Cardiac conduction velocity
ECG basics
ECG intervals
ECG axis
ECG cardiac hypertrophy and enlargement
ECG cardiac infarction and ischemia
Transposition of the great vessels
Tetralogy of Fallot
Persistent truncus arteriosus
Total anomalous pulmonary venous return
Hypoplastic left heart syndrome
Patent ductus arteriosus
Coarctation of the aorta
Ventricular septal defect
Atrial septal defect
Human herpesvirus 8 (Kaposi sarcoma)
Lymphangioma
Chronic venous insufficiency
Vasculitis
Behcet's disease
Aortic dissection
Marfan syndrome
Myocarditis
Endocarditis
Rheumatic heart disease
Pericarditis and pericardial effusion
Cardiac tamponade
Arterial disease
Angina pectoris
Unstable angina
Myocardial infarction
Prinzmetal angina
Hypertension
Hypertensive emergency
Renal artery stenosis
Orthostatic hypotension
Hypotension
Atrial flutter
Atrial fibrillation
Dilated cardiomyopathy
Restrictive cardiomyopathy
Hypertrophic cardiomyopathy
Atherosclerosis and arteriosclerosis: Pathology review
Coronary artery disease: Pathology review
Valvular heart disease: Pathology review
Cardiomyopathies: Pathology review
Dyslipidemias: Pathology review
Hypertension: Pathology review
Endocarditis: Pathology review
Pericardial disease: Pathology review
Shock
Shock: Clinical
Shock: Pathology review
Premature atrial contraction
Wolff-Parkinson-White syndrome
Atrioventricular nodal reentrant tachycardia (AVNRT)
Ventricular tachycardia
Premature ventricular contraction
Ventricular fibrillation
Brugada syndrome
Long QT syndrome and Torsade de pointes
Atrioventricular block
Bundle branch block
Heart failure
Cor pulmonale
Heart failure: Clinical
Heart failure: Pathology review
Positive inotropic medications
Lipid-lowering medications: Statins
Lipid-lowering medications: Fibrates
Miscellaneous lipid-lowering medications
Class III antiarrhythmics: Potassium channel blockers
Class I antiarrhythmics: Sodium channel blockers
Class II antiarrhythmics: Beta blockers
Class IV antiarrhythmics: Calcium channel blockers and others
cGMP mediated smooth muscle vasodilators
Adrenergic antagonists: Beta blockers
Calcium channel blockers
ACE inhibitors, ARBs and direct renin inhibitors
Thiazide and thiazide-like diuretics
Ventricular arrhythmias: Pathology review
Acyanotic congenital heart defects: Pathology review
Cyanotic congenital heart defects: Pathology review
Cardiac tumors
Dressler syndrome
Familial hypercholesterolemia
Abetalipoproteinemia
Hypertriglyceridemia
Hyperlipidemia
Pheochromocytoma
Antihistamines for allergies
Mycobacterium avium complex (NORD)
Nocardia
Pneumocystis jirovecii (Pneumocystis pneumonia)
Cryptococcus neoformans
Coccidioidomycosis and paracoccidioidomycosis
Histoplasmosis
Blastomycosis
Aspergillus fumigatus

Transcript

Watch video only

Over a billion people around the world have hypertension, or high blood pressure, so that pretty much means it’s pretty common. 

Let’s start by defining it. Typically, it’s represented by two numbers: the top number is the systolic blood pressure, which is the arterial pressure when the heart’s contracting; and the lower number is the diastolic blood pressure, which is the arterial pressure when the heart’s relaxing or refilling. Most of the time, blood pressure is taken in the brachial artery in your upper arm, because if the pressure is high there, it’s probably high throughout all of the arteries.

The guidelines for categorizing blood pressure have recently changed to reflect a growing body of evidence that shows that even moderately high blood pressures can significantly increase your risk for developing heart disease. Now, ‘normal’ systolic blood pressure is defined as less than 120 mmHg, and a normal diastolic pressure is less than 80 mmHg. Elevated systolic blood pressure is considered between 120 and 129 mmHg and less than 80 mmHg on the diastolic side. Stage 1 hypertension is between 130 and 139 mmHg on the systolic side, and between 80 and 89 mmHg on the diastolic side. Stage 2 hypertension is defined as anything that is 140 mmHg or higher on the Systolic side and 90 mmHg or higher on the diastolic side.

Typically, both systolic and diastolic pressures tend to climb or fall together, but that’s not always the case. Sometimes, you can have systolic or diastolic hypertension, when one number is normal and the other is really high. This is referred to as isolated systolic hypertension or isolated diastolic hypertension. 

High blood pressure is a serious problem for the blood vessels because it causes wear and tear on the endothelial cells that line the inside of the blood vessels. Just like a garden hose that’s always under high pressure, in the long term, blood vessels can develop tiny cracks and tears that can lead to serious problems, like myocardial infarctions, aneurysms, and strokes.

Now, about 90% of the time, hypertension happens without a clearly identifiable underlying reason. We call this primary hypertension, or essential hypertension. In other words, over time, pressure in the arteries starts to silently creep up.  And there are a bunch of risk factors that we’ve identified for primary hypertension. And these include: old-age, obesity, salt-heavy diets, and sedentary lifestyles. 

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "Arterial hypertension" Hellenic J Cardiol (2013 Sep)
  5. "Arterial hypertension in the light of current recommendations" Terapevticheskii arkhiv (2018)
  6. "Gender-specific therapeutic approach in arterial hypertension – Challenges ahead" Pharmacological Research (2019)