Standard error of the mean (Central limit theorem)

Last updated: June 19, 2025

Standard error of the mean (Central limit theorem)

523

523

Glycolysis
Citric acid cycle
Electron transport chain and oxidative phosphorylation
Pentose phosphate pathway
Gluconeogenesis
Anticoagulants: Heparin
Anticoagulants: Warfarin
Anticoagulants: Direct factor inhibitors
Thrombolytics
Antiplatelet medications
Mean, median, and mode
Range, variance, and standard deviation
Standard error of the mean (Central limit theorem)
Normal distribution and z-scores
Paired t-test
Two-sample t-test
Hypothesis testing: One-tailed and two-tailed tests
Correlation
Type I and type II errors
Sensitivity and specificity
Positive and negative predictive value
Test precision and accuracy
Incidence and prevalence
Relative and absolute risk
Odds ratio
Mortality rates and case-fatality
DALY and QALY
Direct standardization
Indirect standardization
Ecologic study
Glycogen metabolism
Physiological changes during exercise
Amino acid metabolism
Nitrogen and urea cycle
Fatty acid synthesis
Fatty acid oxidation
Ketone body metabolism
Cholesterol metabolism
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Lactose intolerance
Cellular structure and function
Cell membrane
Selective permeability of the cell membrane
Extracellular matrix
Cell-cell junctions
Endocytosis and exocytosis
Osmosis
Resting membrane potential
Nernst equation
Cytoskeleton and intracellular motility
Staphylococcus epidermidis
Staphylococcus aureus
Staphylococcus saprophyticus
Streptococcus viridans
Streptococcus pneumoniae
Streptococcus pyogenes (Group A Strep)
Streptococcus agalactiae (Group B Strep)
Enterococcus
Clostridium botulinum (Botulism)
Clostridium perfringens
Clostridium difficile (Pseudomembranous colitis)
Clostridium tetani (Tetanus)
Bacillus cereus (Food poisoning)
Listeria monocytogenes
Corynebacterium diphtheriae (Diphtheria)
Bacillus anthracis (Anthrax)
Nocardia
Escherichia coli
Salmonella (non-typhoidal)
Salmonella typhi (typhoid fever)
Varicella zoster virus
Epstein-Barr virus (Infectious mononucleosis)
Human herpesvirus 8 (Kaposi sarcoma)
Herpes simplex virus
Human herpesvirus 6 (Roseola)
Adenovirus
Parvovirus B19
Human papillomavirus
BK virus (Hemorrhagic cystitis)
JC virus (Progressive multifocal leukoencephalopathy)
Pseudomonas aeruginosa
Enterobacter
Klebsiella pneumoniae
Shigella
Proteus mirabilis
Yersinia enterocolitica
Legionella pneumophila (Legionnaires disease and Pontiac fever)
Serratia marcescens
Bacteroides fragilis
Yersinia pestis (Plague)
Cell signaling pathways
Nuclear structure
DNA structure
Transcription of DNA
Translation of mRNA
Amino acids and protein folding
Nucleotide metabolism
DNA replication
Lac operon
DNA damage and repair
Inflammation
Ischemia
Free radicals and cellular injury
Necrosis and apoptosis
Atrophy, aplasia, and hypoplasia
Metaplasia and dysplasia
Hyperplasia and hypertrophy
Oncogenes and tumor suppressor genes
Cell cycle
Mitosis and meiosis

Transcript

Watch video only

Let’s say you ask 1000 men for their weights and then plot those weights on a histogram, which is a type of plot that shows the distribution of measurements or data.

So let’s say that the majority of men weighed the same as the average - which in this case might be 170 pounds, or around 77 kilograms - while fewer men weighed a little bit higher or a little bit lower than the average, and even fewer men weighed much higher or much lower than the average.

If we draw a curve over the top of our histogram, we get the normal distribution curve, which is also called the bell curve, because it’s shaped like a bell.

The bell curve is symmetrical, with half the data on the left of the average and half the data on the right side of the average.

The area under the bell curve is equal to 1, or 100%, with the highest percentage of data in the middle section and the lowest percentage of data in the outer tails of the curve.

Typically, for population data, the average point in a bell curve is labeled with the greek letter mu, and mu refers to the mean, median, and mode, because when data are normally distributed, the mean, median, and mode are all equal to each other.

The standard deviation is a measure of how spread out the data are from the average, and for population data it’s represented by the lowercase greek letter sigma.

For example, let’s say the standard deviation of weight for our sample of men is 29 pounds, or 13 kilograms.

In a normal distribution, 68 percent of the data are found within one standard deviation.

That means that 68 percent of men will weigh somewhere between 170 minus 29, or 141 pounds, and 170 plus 29, or 199 pounds.

Also, 95 percent of the data are found within two standard deviations - so, since 29 times 2 is 58, then 95 percent of men will weigh somewhere between 170 minus 58, or 112 pounds, and 170 plus 58, or 228 pounds.

Finally, 99.7 percent the data are found within three standard deviations, and since 29 times 3 is 87, 99.7% of men will weigh between 170 minus 87, or 83 pounds, and 170 plus 87, or 257 pounds.

This is called the empirical rule, or the 68-95-99.7 rule.

Now, the shape of the bell curve depends on the size of the standard deviation.

A small standard deviation, like if it was only 5 pounds, tells you that most of the data are clustered around the average - and this makes the bell curve very tall and skinny.

On the other hand, a large standard deviation, like if it was 50 pounds, tells you that most of the data are way above and way below the average - and this makes the bell curve look very wide and flat.

It’s also possible that the population of 1000 men have a skewed distribution instead of a normal distribution, meaning one tail of the bell curve is longer than the other.

A right-skewed distribution means that the right tail is longer than the left tail, and a left-skewed distribution means that the left tail is longer than the right tail.

Typically, when the distribution is skewed, the mean, median, and mode are not equal.

Oftentimes it’s impossible to collect measurements from every single person in the population, so we choose a sample which is basically a small number of people that we think represent the larger group.

As a general rule, if we collect the sample randomly, meaning people are chosen solely by chance, then we expect that sample to have similar characteristics - like the same distribution of weight - as the population they’re chosen from.

And if the two groups have similar characteristics, we also expect that the mean and the standard deviation to be the same in the two groups.

For example, let’s say we randomly take a sample of 50 men from the total population of 1000 men.

If the population has a mean weight of 170 pounds and a standard deviation of 29 pounds, we also expect the sample to have a mean weight of 170 pounds and a standard deviation of 29 pounds.

But in some cases the sample we collect won’t have a mean of exactly 170.

For example, a random sample of people might weigh more than the population mean, so the sample mean will be higher than the population mean.

Key Takeaways

Central limit theorem states that if the desired data is obtained repeatedly from random samples and the mean is calculated for each sample, these means will form a normal Gaussian curve.This curve will always be normal regardless to the shape of the original curve. The standard deviation of this curve is called the standard error of mean.The standard error of mean does not measure the dispersion of data but measures how much the sample represents the population. It is directly proportional to standard deviation and inversely proportional to sample size.