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Before we begin, a quick terminology update. In 2026, an international group of patient advocacy and professional organizations introduced a new name for the condition previously known as Polycystic Ovary Syndrome, or PfCOS.

PCOS is transitioning to Polyendocrine Metabolic Ovarian Syndrome, or PMOS. The new name was introduced because the condition involves much more than just the ovaries and can affect body weight, metabolism, mental health, skin, and reproductive function.

The old name emphasized ovarian cysts rather than the broader endocrine and metabolic features of the condition, which may have contributed to misunderstanding, delayed diagnosis, and inadequate treatment.

As you watch the video, keep in mind that any references to PCOS refer to the condition newly named PMOS. The underlying disease process and management discussed in this video remain the same.

Infertility is defined as the inability to conceive after 12 months of regular, unprotected sexual intercourse in couples of reproductive age. Infertility can affect one or both partners, or, in some cases, no cause can be found in either partner, in which case it’s termed unexplained infertility.

Now, let’s go over some anatomy and physiology when it comes to conceiving. The female gonads are called ovaries, which are paired reproductive organs that produce sex hormones, namely estrogen and progesterone; as well as gametes, called oocytes, in the process known as oogenesis.

These functions are an integral part of the menstrual cycle, which usually lasts around 28 days and can be divided in two phases. First, there’s the follicular phase, during which estrogen rises, and the oocytes mature until ovulation, which typically occurs on day 14 of a 28-day cycle.

During ovulation, the mature oocyte is released in the fallopian tube, and it can possibly be fertilized by a male gamete, called a sperm. If fertilization occurs, the fertilized egg travels down the Fallopian tube and implants into the uterine lining, so pregnancy occurs.