Due to its critical role in becoming a physician, the USMLE Step 2® exam requires little to no introduction. With USMLE Step 1 now graded as pass/fail, Step 2 has become a key factor in residency applications, with more emphasis placed on exam performance than ever before. As a result, medical students need to prioritize thoroughly preparing for USMLE Step 2 to stand out from their peers.
While Step 1 covers the first two years of medical school, Step 2 focuses on the content and cases experienced during clinical rotations. Not surprisingly, Step 2 questions will feel more clinical, as many of the questions focus on diagnosis, treatment, and management, as opposed to the Basic Sciences content emphasized in Step 1. The good news is that because you’ve been actively learning and applying what you’ve learned as part of your clinical work, you’ve been studying all along!
Regardless of your learning style, studying preferences, or schedule, Osmosis.org is a valuable resource for your dedicated period for Step 2. And while preparing for Step 2 can feel similar to preparing for Step 1, there are some crucial differences. Let’s explore those differences and highlight the best ways to use question banks, like the Osmosis Step 2 quiz library, to maximize your study time.
Understanding the USMLE Step 2 Exam
Step 2 consists of two distinct portions: the Clinical Skills section (CS) and the Clinical Knowledge (CK) section. Compared to the USMLE Step 1 or the MCAT, which both emphasize basic sciences and foundational knowledge, Step 2 focuses more on applying clinical reasoning, diagnosis, treatment, and patient management in real-world medical scenarios. In other words, while USMLE Step 1 focuses on the “whys” and “hows” of medicine, Step 2 focuses more on “Now that you know the mechanism, how do you arrive at the right diagnosis?” along with “Now that you know what they have, what do you do about it?”
For many students, the shift to studying for USMLE Step 2 can be a relief, especially for those tired of memorizing obscure biochemical pathways or bacterial coding sequences. Step 2 often feels like less of a chore to study for because it focuses on the clinical knowledge that students want to learn in the first place.
However, don’t completely forget the basics from Step 1, as you never know when Step 2 will throw you a curveball, like asking, “Which of the following treatment options both indirectly and directly activates the mTOR pathway?” (Hint: it’s a psychiatry medication; share your best guess in the comments below!)
Similar to Step 1, using question banks for Step 2 can help you build on what you’ve already learned. Just make sure to incorporate some Step 1 questions to keep that knowledge fresh in your mind!
Getting Started with Osmosis
Let’s begin by creating an Osmosis account (in case you aren’t a current subscriber, free trials are available to explore Osmosis before you sign up). Once you log into the platform, accessing Osmosis quizzes is as simple as clicking on the left sidebar menu, where you’ll find the “Questions” section.

Now it’s time to choose which exam you’re preparing for (see figure 2). The Osmosis app will guide you through building and tailoring a practice question session for your current study goals, enabling seamless integration into any study plan, including those that focus on specific systems for a set number of days or those that review all content from the start (an awe-inspiring feat)!

Please note that you can select from new questions, questions you’ve previously answered incorrectly, or a combination of both, enabling you to create question sets that emphasize new content or review previously covered material.
Using Osmosis Quizzes Effectively
When preparing for Step 2, set clear daily study goals that fit within a structured weekly schedule to ensure you cover as much content as possible. For a structured weekly plan, several possible frameworks are available for Step 2. For example, you can split the study period into two halves, with the first half dedicated to focusing on specific clinical rotations and relevant question sets and the second half devoted to mixed question sets.
For example, here’s what a study schedule might look like for students using this approach, with three days scheduled to focus on cardiology:
First Four-Week Average Day Specific Clinical Rotation Questions | Last Four-Week Average Day Mixed Questions |
8 AM-12 PM: Cardiology Specific content review 12-1 PM: Lunch Break 1-4 PM: Cardiology specific practice questions & review. | 8 AM-12 PM: Mixed, timed question sets and review. 12-1 PM: Lunch Break 1-4 PM: Mixed, timed question sets and review |
One important thing to note about this study schedule is the relative symmetry between the first and last half of a dedicated period, which allows for habit-building and predictability in your study habits. It also begins with less time spent focusing specifically on practice questions and gradually increases the time spent per day on questions as Step 2 approaches, allowing you to build endurance and confidence as you progress.
Additionally, keep in mind that this is just one example. If this study plan doesn’t work for you, trust your instincts! Additionally, when scheduling your study time, it’s often best to determine what’s worked for you in previous exams (such as the MCAT or Step 1) and apply those strategies to studying for Step 2. Regardless of the approach you choose, the Osmosis quiz builder is flexible enough to adjust to your needs.
Strategies for Maximizing Quiz Benefits
While completing practice questions is essential for doing well on Step 2, there are other noteworthy elements of studying that you should leverage. Using the above example as a typical day of studying, please note that both phases of the study plan set aside time for reviewing content because reviewing content is as important, if not more important, than learning new content!
Additionally, since Step 2 is a cumulative exam that covers three years of medical school, so regularly reviewing past concepts is crucial because it promotes memory consolidation and concept mastery, which ultimately helps you become a better doctor. And that is, after all, what this is all about!
Using Anki to Review for Step 2
You’ve likely heard of Anki, a free, open-source flashcard app designed to enhance long-term memory using a learning strategy called spaced repetition. This method adjusts how often you see each card, showing easier topics less frequently and focusing more on challenging concepts.
If you decide to use Anki, keep in mind that it wasn’t designed for learning new material. If you use Anki, creating your own cards is the most effective way to ensure that you’re not spending hours on Anki daily, because each card you review is tailored specifically to your strengths and weaknesses, making your study time more efficient. However, if making cards for every topic feels overwhelming, it’s likely just as effective to make an Anki deck consisting of only the concepts you feel you need more help with because it requires less card creation in the end. This advice isn’t intended to discourage the use of pre-made decks but to help you avoid the common trap of spending excessive time without making any meaningful progress (like reviewing 4,000 cards in five hours).
Tips for Success on the USMLE Step 2 Exam
While creating an ideal study plan that allows consistent, predictable progress is a huge part of performing well on Step 2, there are other variables worth considering, such as awareness of your test-taking habits. For example, when you’re completing and reviewing practice question sets, pay attention to your test-taking habits, e.g., changing answers from correct to incorrect or vice versa. Keeping track of these variables is the first step towards identifying maladaptive versus productive test-taking habits you may be prone to leaning on.
The Importance of Time Management
In addition to your test-taking habits, effective time management is another crucial aspect of maximizing your study time. As noted in the example study schedule, timed question blocks are a great way to keep track of the time you spend.
Why Self-Care Is Key
In addition to effectively managing your time, it’s important to practice self-care and make space for a life outside of studying. For example, the study schedule we shared above ranges from 8 AM to 4 PM, allowing you to devote your evening hours to rest, social connection, hobbies, or simply getting adequate sleep.
For anyone who feels guilty or uneasy when they’re not studying, try thinking of wellness and self-care activities as essential, not optional. Research shows that taking regular breaks during study sessions improves focus and memory retention. Focusing on your well-being isn’t being lazy; it’s the foundation that makes hard work possible.
Take Advantage of ADA Accommodations
For those students who qualify for test-taking accommodations through the ADA, we strongly recommend submitting the necessary documents to the USMLE as early as possible, even if it’s just to have the option available. There’s absolutely no shame in accommodations; the USMLE Step 2 is a demanding exam. Having the support you need can make a meaningful difference in both your peace of mind and exam performance.
Key Takeaways and Final Study Tips
We hope you’ve found this guide to be a valuable framework for how to approach your Step 2 dedicated study period. Establishing a study framework that’s easy to adhere to, consistent, and repeatable while practicing adequate self-care is the foundation for achieving an excellent score on Step 2. Remember to monitor your test-taking habits, reach out to utilize accommodations if needed, and prioritize your well-being throughout the process. A balanced approach not only improves memory retention but also helps you stay motivated during a critical step in your medical education journey.
Make sure to let us know in the comments which concepts or study topics you’d like us to review next. And happy studying!

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