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autoantibody p. 113
type II hypersensitivity p. 110
bullous pemphigoid p. 493
Bullous pemphigoid is an autoimmune skin disease that causes the skin to form bullae or blisters.
The epidermis forms the thin outermost layer of skin.
The epidermis itself is made of multiple layers of developing keratinocytes - which are flat pancake-shaped cells that are named for the keratin protein that they’re filled with.
Keratinocytes start their life at the lowest layer of the epidermis called the stratum basale, or basal layer which is made of a single layer of stem cells, called basal cells that continually divide and produce new keratinocytes.
The stratum basale also contains another group of cells called melanocytes, which secrete melanin.
Melanin is a pigment protein, or coloring substance.
Below the epidermis is the basement membrane which is a thin layer of delicate tissue containing collagen, laminins, and other proteins.
Basal cells are attached to the basement membrane by hemidesmosomes, a protein complex that stems from the bottom of the basal cells.
Just like an anchor digs into the seafloor and holds a boat in place, hemidesmosomes dig into the basement membrane and hold basal cells in place.
The exact cause of bullous pemphigoid is unclear, but it’s thought that in a person with a genetic precondition, it can be triggered by medications like furosemide, captopril, penicillamine, non steroid anti-inflammatory drugs (or NSAIDs), and antibiotics.
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