Burns: Clinical sciences

Last updated: January 30, 2025

Burns: Clinical sciences

Pediatrics

Pediatrics

Approach to acid-base disorders: Clinical sciences
Approach to metabolic acidosis: Clinical sciences
Approach to metabolic alkalosis: Clinical sciences
Approach to respiratory acidosis: Clinical sciences
Approach to respiratory alkalosis: Clinical sciences
Approach to hypernatremia (pediatrics): Clinical sciences
Approach to hypocalcemia (pediatrics): Clinical sciences
Approach to hypoglycemia (pediatrics): Clinical sciences
Approach to hyponatremia (pediatrics): Clinical sciences
Adrenal insufficiency: Clinical sciences
Syndrome of inappropriate antidiuretic hormone secretion: Clinical sciences
Adnexal torsion: Clinical sciences
Appendicitis: Clinical sciences
Approach to abdominal wall and groin masses: Clinical sciences
Approach to dysmenorrhea: Clinical sciences
Cholecystitis: Clinical sciences
Ectopic pregnancy: Clinical sciences
Henoch-Schonlein purpura: Clinical sciences
Inflammatory bowel disease (Crohn disease): Clinical sciences
Inflammatory bowel disease (ulcerative colitis): Clinical sciences
Intussusception: Clinical sciences
Irritable bowel syndrome: Clinical sciences
Pelvic inflammatory disease: Clinical sciences
Testicular torsion (pediatrics): Clinical sciences
Urinary tract infection (pediatrics): Clinical sciences
Approach to anemia (destruction and sequestration): Clinical sciences
Approach to anemia (underproduction): Clinical sciences
Approach to anemia in the newborn and infant (destruction and blood loss): Clinical sciences
Approach to anemia in the newborn and infant (underproduction): Clinical sciences
Approach to leukemia: Clinical sciences
Iron deficiency and iron deficiency anemia (pediatrics): Clinical sciences
Sickle cell disease: Clinical sciences
Approach to bleeding disorders (platelet dysfunction): Clinical sciences
Approach to bleeding disorders (thrombocytopenia): Clinical sciences
Immune thrombocytopenia: Clinical sciences
Meningitis (pediatrics): Clinical sciences
Sepsis (pediatrics): Clinical sciences
Celiac disease: Clinical sciences
Asthma: Clinical sciences
Bronchiolitis: Clinical sciences
Congestive heart failure: Clinical sciences
COVID-19: Clinical sciences
Croup and epiglottitis: Clinical sciences
Cystic fibrosis and primary ciliary dyskinesia: Clinical sciences
Influenza: Clinical sciences
Pneumonia (pediatrics): Clinical sciences
Tuberculosis (pulmonary): Clinical sciences
Upper respiratory tract infections: Clinical sciences
Clostridioides difficile infection: Clinical sciences
Approach to a fever (over 2 months): Clinical sciences
Acute rheumatic fever and rheumatic heart disease: Clinical sciences
Osteomyelitis (pediatrics): Clinical sciences
Otitis media and externa (pediatrics): Clinical sciences
Pharyngitis, peritonsillar abscess, and retropharyngeal abscess (pediatrics): Clinical sciences
Septic arthritis and transient synovitis (pediatrics): Clinical sciences
Stevens-Johnson syndrome and toxic epidermal necrolysis: Clinical sciences
Tuberculosis (extrapulmonary and latent): Clinical sciences
Approach to bacterial causes of fever and rash (pediatrics): Clinical sciences
Acute group A streptococcal infections and sequelae (pediatrics): Clinical sciences
Approach to congenital infections: Clinical sciences
Juvenile idiopathic arthritis: Clinical sciences
Kawasaki disease: Clinical sciences
Lyme disease: Clinical sciences
Periorbital and orbital cellulitis (pediatrics): Clinical sciences
Toxic shock syndrome: Clinical sciences
Staphylococcal scalded skin syndrome and impetigo: Clinical sciences
Approach to a murmur (pediatrics): Clinical sciences
Approach to congenital heart diseases (acyanotic): Clinical sciences
Approach to congenital heart diseases (cyanotic): Clinical sciences
Hypertrophic cardiomyopathy: Clinical sciences
Approach to hepatic masses: Clinical sciences
Hepatitis A and E: Clinical sciences
Hepatitis B: Clinical sciences
Hepatitis C: Clinical sciences
Approach to a limp (pediatrics): Clinical sciences
Approach to a suspected bone tumor (pediatrics): Clinical sciences
Developmental dysplasia of the hip: Clinical sciences
Legg-Calve-Perthes disease and slipped capital femoral epiphysis: Clinical sciences
Approach to peripheral lymphadenopathy (pediatrics): Clinical sciences
Approach to a red eye: Clinical sciences
Approach to vomiting (newborn and infant): Clinical sciences
Acetaminophen (Paracetamol) toxicity: Clinical sciences
Approach to recreational substance exposure (pediatrics): Clinical sciences
Diabetes mellitus (pediatrics): Clinical sciences
Large bowel obstruction: Clinical sciences
Pyloric stenosis: Clinical sciences
Small bowel obstruction: Clinical sciences
Approach to a fever (0-60 days): Clinical sciences
Approach to jaundice (newborn and infant): Clinical sciences
Non-accidental trauma and neglect (pediatrics): Clinical sciences
Necrotizing enterocolitis: Clinical sciences
Neonatal respiratory distress syndrome: Clinical sciences
Approach to respiratory distress (newborn): Clinical sciences
Approach to cyanosis (newborn): Clinical sciences
Approach to shock (pediatrics): Clinical sciences
Approach to lower airway obstruction (pediatrics): Clinical sciences
Approach to upper airway obstruction (pediatrics): Clinical sciences
Anaphylaxis: Clinical sciences
Foreign body aspiration and ingestion (pediatrics): Clinical sciences
Approach to a first unprovoked seizure (pediatrics): Clinical sciences
Febrile seizure (pediatrics): Clinical sciences
Approach to bradycardia: Clinical sciences
Approach to tachycardia: Clinical sciences
Brief, resolved, unexplained event (BRUE): Clinical sciences
Approach to hematochezia (pediatrics): Clinical sciences
Burns: Clinical sciences
Neurogenic shock: Clinical sciences
Approach to delayed puberty: Clinical sciences
Approach to feeding and eating disorders: Clinical sciences
Approach to neurodevelopmental disorders: Clinical sciences
Approach to precocious puberty: Clinical sciences
Approach to short stature: Clinical sciences
Autism spectrum disorder: Clinical sciences
Approach to a child with Down syndrome (trisomy 21): Clinical sciences
Dyslipidemia: Clinical sciences
Essential hypertension: Clinical sciences
Developmental milestones (newborn and infant): Clinical sciences
Developmental milestones (toddler): Clinical sciences
Developmental milestones (childhood): Clinical sciences
Approach to a rash in the well newborn and infant: Clinical sciences
Immunizations (pediatrics): Clinical sciences
Well-child visit (adolescent): Clinical sciences
Well-child visit (newborn and infant): Clinical sciences
Well-child visit (toddler and child): Clinical sciences
Well-patient care (GYN): Clinical sciences
Sports physical (pediatrics): Clinical sciences
Antidiuretic hormone
Body fluid compartments
Movement of water between body compartments
Sodium homeostasis
Acid-base disturbances: Pathology review
Diabetes insipidus and SIADH: Pathology review
Electrolyte disturbances: Pathology review
Renal failure: Pathology review
Acyanotic congenital heart defects: Pathology review
Adrenal masses: Pathology review
Bacterial and viral skin infections: Pathology review
Bone tumors: Pathology review
Coagulation disorders: Pathology review
Congenital neurological disorders: Pathology review
Cyanotic congenital heart defects: Pathology review
Extrinsic hemolytic normocytic anemia: Pathology review
Eye conditions: Inflammation, infections and trauma: Pathology review
Eye conditions: Refractive errors, lens disorders and glaucoma: Pathology review
Headaches: Pathology review
Intrinsic hemolytic normocytic anemia: Pathology review
Leukemias: Pathology review
Lymphomas: Pathology review
Macrocytic anemia: Pathology review
Microcytic anemia: Pathology review
Mixed platelet and coagulation disorders: Pathology review
Nasal, oral and pharyngeal diseases: Pathology review
Nephritic syndromes: Pathology review
Nephrotic syndromes: Pathology review
Non-hemolytic normocytic anemia: Pathology review
Pediatric brain tumors: Pathology review
Pediatric musculoskeletal disorders: Pathology review
Platelet disorders: Pathology review
Renal and urinary tract masses: Pathology review
Seizures: Pathology review
Viral exanthems of childhood: Pathology review
Adrenal insufficiency: Pathology review
Central nervous system infections: Pathology review
Childhood and early-onset psychological disorders: Pathology review
Congenital gastrointestinal disorders: Pathology review
Diabetes mellitus: Pathology review
Environmental and chemical toxicities: Pathology review
Gastrointestinal bleeding: Pathology review
GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review
Inflammatory bowel disease: Pathology review
Medication overdoses and toxicities: Pathology review
Obstructive lung diseases: Pathology review
Pneumonia: Pathology review
Psychiatric emergencies: Pathology review
Shock: Pathology review
Supraventricular arrhythmias: Pathology review
Traumatic brain injury: Pathology review
Ventricular arrhythmias: Pathology review
Congenital TORCH infections: Pathology review
Jaundice: Pathology review
Respiratory distress syndrome: Pathology review
Autosomal trisomies: Pathology review
Cystic fibrosis: Pathology review
Disorders of sex chromosomes: Pathology review
HIV and AIDS: Pathology review
Miscellaneous genetic disorders: Pathology review
Papulosquamous and inflammatory skin disorders: Pathology review
Anxiety disorders, phobias and stress-related disorders: Pathology Review
Developmental and learning disorders: Pathology review
Eating disorders: Pathology review
Mood disorders: Pathology review
Breastfeeding
Pharmacodynamics: Agonist, partial agonist and antagonist
Pharmacodynamics: Desensitization and tolerance
Pharmacodynamics: Drug-receptor interactions
Pharmacokinetics: Drug absorption and distribution
Pharmacokinetics: Drug elimination and clearance
Pharmacokinetics: Drug metabolism
Androgens and antiandrogens
Estrogens and antiestrogens
Miscellaneous cell wall synthesis inhibitors
Protein synthesis inhibitors: Tetracyclines
Cell wall synthesis inhibitors: Penicillins
Antihistamines for allergies
Acetaminophen (Paracetamol)
Non-steroidal anti-inflammatory drugs
Antimetabolites: Sulfonamides and trimethoprim
Antituberculosis medications
Cell wall synthesis inhibitors: Cephalosporins
DNA synthesis inhibitors: Fluoroquinolones
DNA synthesis inhibitors: Metronidazole
Miscellaneous protein synthesis inhibitors
Protein synthesis inhibitors: Aminoglycosides
Bronchodilators: Beta 2-agonists and muscarinic antagonists
Bronchodilators: Leukotriene antagonists and methylxanthines
Pulmonary corticosteroids and mast cell inhibitors
Glucocorticoids
Azoles
Anticonvulsants and anxiolytics: Barbiturates
Anticonvulsants and anxiolytics: Benzodiazepines
Nonbenzodiazepine anticonvulsants

Decision-Making Tree

Transcript

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Burns are injuries caused by heat, cold, friction, radiation, electricity, or chemical exposure. When significant heat is applied to the skin, either in the form of a hot liquid, solid object, or flame, this thermal energy can result in irreversible tissue destruction. Extensive tissue destruction, especially in burns larger than 40% of the total body surface area, or TBSA; can cause fluid loss, and with it, hypovolemic shock! Burns are classified based on the depth of injury into first-, second-, third-, and fourth-degree burns, as well as burns accompanied by smoke inhalation.

When evaluating a patient with burns, your first step should be an ABCDE assessment to see if the patient is unstable or stable. If the patient is unstable, first stabilize their airway, breathing, and circulation. This means that you may need to intubate the patient, obtain IV access, and administer fluids before continuing with your assessment.

Now let’s move on to the stable patients. If your patient is stable, start with a focused history and physical examination. History reveals thermal injury and can identify the mechanism of injury, such as hot liquids, flames, or grease. The physical exam will vary depending on the depth of the burn.

Some burns might be accompanied by smoke inhalation, so let’s talk about that. History might reveal delayed extrication from a fire in an enclosed space. On physical examination, your patient may have facial burns, singed facial hair, wheezing, or stridor. They may also cough up carbonaceous material, or soot.

Once you suspect inhalation injury, you should obtain labs, including an ABG and carboxyhemoglobin level. Findings may include decreased paO2 and oxygen saturation. However, ABG might be completely normal initially. When it comes to carboxyhemoglobin, in non-smokers with inhalation injury it might increase over 3%; however, in smokers, those levels might be greater than 10%, since they are chronically exposed to carbon monoxide from tobacco smoke.

Next, order a chest x-ray. The initial chest x-ray can be normal; however, it is important to establish a baseline evaluation of the lungs. If your patient is intubated, you should also perform a bronchoscopy, which may show carbonaceous deposits, edema, and erythema throughout the airway. Other findings include bronchorrhea, or copious sputum, and bronchial obstruction. Mucosal sloughing typically appears later as bronchial inflammation worsens due to chemical byproducts in the inhaled smoke. Based on all these findings, you can diagnose inhalation injury.

The next step is to start inpatient management. This includes administering high-flow oxygen to maintain oxygen saturations above 90%. If the patient develops drooling, wheezing, or stridor, or is unable to maintain oxygen saturations higher than 90%, they should be intubated if they aren’t already. In an intubated patient, you can also perform serial bronchoscopies to monitor the progression of the injury and wash out any carbonaceous material within the lungs.

Burns are classified based on the depth of injury into first-, second-, third-, and fourth-degree burns. Let’s switch gears and talk about first-degree burns, also known as superficial because they involve only the epidermis. To remember first-degree burns, just imagine a sunburn. So, on physical exam, the skin is soft; it blanches when pressure is applied; and is typically painful. If you see this, then you are dealing with a first-degree burn. Once you diagnose a first-degree burn, you can treat them on an outpatient basis. Management includes wound care, like cleaning the burn with cool tap water and mild soap and applying topical analgesia such as aloe vera if needed. If they require additional pain management, acetaminophen is usually sufficient.

Now, let’s move on to second-degree burns, also called partial thickness burns since they extend into the dermis. On a physical exam, the involved skin is usually warm, soft, and erythematous, and there might be pain to palpation. The skin may blanch when pressure is applied; however, blistering is often present. Deep second-degree wounds are less painful since some nerve endings have been damaged. They also blanch less than superficial ones.

Alright, let’s switch gears and talk about third-degree burns. Third-degree burns, also called full-thickness burns, are deeper and extend to the subcutaneous fat. Patients usually report little or no pain, due to significant nerve damage. On physical exam, the skin may appear white, brown, or charred, feel firm or leathery, and doesn’t blanch with pressure. Lastly, let’s talk about the most severe burn category, fourth-degree burns. In fourth-degree burns, there is little or no pain due to extensive tissue necrosis. On exam, the skin appears charred, and the burn extends down to the muscle, tendon, or bone.

Sources

  1. "American Burn Association Clinical Practice Guidelines on Burn Shock Resuscitation" J Burn Care Res (2023)
  2. "American Burn Association Guidelines on the Management of Acute Pain in the Adult Burn Patient: A Review of the Literature, a Compilation of Expert Opinion, and Next Steps" J Burn Care Res (2020)
  3. "ATLS advanced trauma life support 10th edition student course manual, 10th ed." American College of Surgeons (2018)
  4. "Acute and perioperative care of the burn-injured patient" Anesthesiology (2015)
  5. "Burns" Schwartz’s Principles of Surgery, 10th ed. (2014)
  6. "Burn injury" Nat Rev Dis Primers (2020)
  7. "Initial management of severe burn injury" Curr Opin Crit Care (2019)
  8. "Diagnosis and management of inhalation injury: an updated review" Crit Care (2015)