Cauda equina syndrome

Cauda equina syndrome

NP Patho

NP Patho

Ischemia
Hypoxia
Free radicals and cellular injury
Necrosis and apoptosis
Inflammation
Atrophy, aplasia, and hypoplasia
Hyperplasia and hypertrophy
Metaplasia and dysplasia
Oncogenes and tumor suppressor genes
Osteoporosis
Osteoarthritis
Osteomalacia and rickets
Lordosis, kyphosis, and scoliosis
Rheumatoid arthritis
Rheumatoid arthritis and osteoarthritis: Pathology review
Psoriatic arthritis
Reactive arthritis
Septic arthritis
Ankylosing spondylitis
Seronegative and septic arthritis: Pathology review
Osteomyelitis
Gout
Gout and pseudogout: Pathology review
Carpal tunnel syndrome
Rotator cuff tear
Meniscus tear
Sciatica
Back pain: Pathology review
Osgood-Schlatter disease (traction apophysitis)
Slipped capital femoral epiphysis
Developmental dysplasia of the hip
Legg-Calve-Perthes disease
Bone tumors
Bone tumors: Pathology review
Bone disorders: Pathology review
Compartment syndrome
Fibromyalgia
Polymyalgia rheumatica
Muscular dystrophy
Muscular dystrophies and mitochondrial myopathies: Pathology review
Myalgias and myositis: Pathology review
Myasthenia gravis
Ischemic stroke
Intracerebral hemorrhage
Cerebral vascular disease: Pathology review
Epidural hematoma
Subdural hematoma
Subarachnoid hemorrhage
Arteriovenous malformation
Migraine
Headaches: Pathology review
Alzheimer disease
Frontotemporal dementia
Vascular dementia
Dementia with Lewy bodies
Normal pressure hydrocephalus
Parkinson disease
Huntington disease
Multiple sclerosis
Pituitary adenoma
Adult brain tumors
Acoustic neuroma (schwannoma)
Cauda equina syndrome
Vitamin B12 deficiency
Meningitis
Neurofibromatosis
Guillain-Barre syndrome
Charcot-Marie-Tooth disease
Bell palsy
Horner syndrome
Spinal cord disorders: Pathology review
Central nervous system infections: Pathology review
Neuromuscular junction disorders: Pathology review
Seizures: Pathology review
Traumatic brain injury: Pathology review
Movement disorders: Pathology review
Demyelinating disorders: Pathology review
Arterial disease
Angina pectoris
Myocardial infarction
Peripheral artery disease
Aneurysms
Aortic dissection
Vasculitis
Kawasaki disease
Hypertension
Hypertriglyceridemia
Familial hypercholesterolemia
Chronic venous insufficiency
Deep vein thrombosis
Thrombophlebitis
Shock
Vascular tumors
Angiosarcomas
Transposition of the great vessels
Tetralogy of Fallot
Hypoplastic left heart syndrome
Patent ductus arteriosus
Ventricular septal defect
Atrial septal defect
Atrial flutter
Atrial fibrillation
Wolff-Parkinson-White syndrome
Ventricular tachycardia
Premature ventricular contraction
Ventricular fibrillation
Long QT syndrome and Torsade de pointes
Atrioventricular block
Bundle branch block
Dilated cardiomyopathy
Hypertrophic cardiomyopathy
Restrictive cardiomyopathy
Heart failure
Cor pulmonale
Endocarditis
Myocarditis
Rheumatic heart disease
Pericarditis and pericardial effusion
Cardiac tamponade
Acyanotic congenital heart defects: Pathology review
Cyanotic congenital heart defects: Pathology review
Atherosclerosis and arteriosclerosis: Pathology review
Coronary artery disease: Pathology review
Peripheral artery disease: Pathology review
Valvular heart disease: Pathology review
Heart failure: Pathology review
Cardiomyopathies: Pathology review
Supraventricular arrhythmias: Pathology review
Ventricular arrhythmias: Pathology review
Aortic dissections and aneurysms: Pathology review
Heart blocks: Pathology review
Hypertension: Pathology review
Endocarditis: Pathology review
Shock: Pathology review
Vasculitis: Pathology review
Dyslipidemias: Pathology review
Allergic rhinitis
Nasal polyps
Upper respiratory tract infection
Sinusitis
Retropharyngeal and peritonsillar abscesses
Laryngitis
Bacterial epiglottitis
Sudden infant death syndrome
Acute respiratory distress syndrome
Emphysema
Chronic bronchitis
Asthma
Alpha 1-antitrypsin deficiency
Cystic fibrosis
Bronchiectasis
Restrictive lung diseases
Idiopathic pulmonary fibrosis
Sarcoidosis
Pneumonia
Lung cancer
Pneumothorax
Pleural effusion
Pulmonary embolism
Pulmonary hypertension
Pulmonary edema
Sleep apnea
Respiratory distress syndrome: Pathology review
Pneumonia: Pathology review
Deep vein thrombosis and pulmonary embolism: Pathology review
Cystic fibrosis: Pathology review
Tuberculosis: Pathology review
Pleural effusion, pneumothorax, hemothorax and atelectasis: Pathology review
Restrictive lung diseases: Pathology review
Obstructive lung diseases: Pathology review
Apnea, hypoventilation and pulmonary hypertension: Pathology review
Lung cancer and mesothelioma: Pathology review
Renal agenesis
Hyponatremia
Hypernatremia
Hypomagnesemia
Hypermagnesemia
Hypokalemia
Hyperkalemia
Hypocalcemia
Hypercalcemia
Diabetic nephropathy
Amyloidosis
Membranous nephropathy
Membranoproliferative glomerulonephritis
Poststreptococcal glomerulonephritis
Kidney stones
Hydronephrosis
Acute pyelonephritis
Chronic kidney disease
Polycystic kidney disease
Renal artery stenosis
Nephroblastoma (Wilms tumor)
Renal cell carcinoma
Hypospadias and epispadias
Bladder exstrophy
Urinary incontinence
Neurogenic bladder
Lower urinary tract infection
Transitional cell carcinoma
Congenital renal disorders: Pathology review
Acid-base disturbances: Pathology review
Renal failure: Pathology review
Nephritic syndromes: Pathology review
Nephrotic syndromes: Pathology review
Electrolyte disturbances: Pathology review
Kidney stones: Pathology review
Congenital adrenal hyperplasia
Primary adrenal insufficiency
Hyperaldosteronism
Cushing syndrome
Hyperthyroidism
Graves disease
Thyroid eye disease (NORD)
Thyroid storm
Hypothyroidism
Hashimoto thyroiditis
Thyroid cancer
Hyperparathyroidism
Hypoparathyroidism
Diabetes mellitus
Prolactinoma
Hyperprolactinemia
Hypoprolactinemia
Constitutional growth delay
Diabetes insipidus
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Neuroblastoma
Pheochromocytoma
Adrenal insufficiency: Pathology review
Adrenal masses: Pathology review
Hypothyroidism: Pathology review
Hyperthyroidism: Pathology review
Parathyroid disorders and calcium imbalance: Pathology review
Hypopituitarism: Pathology review
Thyroid nodules and thyroid cancer: Pathology review
Diabetes mellitus: Pathology review
Diabetes insipidus and SIADH: Pathology review
Precocious puberty
Delayed puberty
Turner syndrome
Klinefelter syndrome
Benign prostatic hyperplasia
Prostate cancer
Testicular cancer
Erectile dysfunction
Amenorrhea
Ovarian cyst
Premature ovarian failure
Polycystic ovary syndrome
Uterine fibroid
Endometriosis
Endometritis
Cervical cancer
Pelvic inflammatory disease
Endometrial cancer
Breast cancer
Preeclampsia & eclampsia
Placenta previa
Placental abruption
Postpartum hemorrhage
Miscarriage
Ectopic pregnancy
Disorders of sex chromosomes: Pathology review
Prostate disorders and cancer: Pathology review
Uterine disorders: Pathology review
Cervical cancer: Pathology review
Benign breast conditions: Pathology review
Testicular tumors: Pathology review
Ovarian cysts and tumors: Pathology review
Vaginal and vulvar disorders: Pathology review
Breast cancer: Pathology review
Amenorrhea: Pathology review
Sexually transmitted infections: Warts and ulcers: Pathology review
Sexually transmitted infections: Vaginitis and cervicitis: Pathology review
HIV and AIDS: Pathology review
Glaucoma
Eustachian tube dysfunction
Sialadenitis
Aphthous ulcers
Oral cancer
Temporomandibular joint dysfunction
Esophageal cancer
Gastroesophageal reflux disease (GERD)
Eye conditions: Refractive errors, lens disorders and glaucoma: Pathology review
Eye conditions: Retinal disorders: Pathology review
Vertigo: Pathology review
Eye conditions: Inflammation, infections and trauma: Pathology review
Nasal, oral and pharyngeal diseases: Pathology review
Pyloric stenosis
Dental abscess
Dental caries disease
Eosinophilic esophagitis (NORD)
Peptic ulcer
Gastric cancer
Hirschsprung disease
Intussusception
Celiac disease
Crohn disease
Ulcerative colitis
Bowel obstruction
Abdominal hernias
Colorectal cancer
Colorectal polyps
Irritable bowel syndrome
Diverticulosis and diverticulitis
Appendicitis
Biliary atresia
Jaundice
Cirrhosis
Portal hypertension
Wilson disease
Non-alcoholic fatty liver disease
Primary sclerosing cholangitis
Viral hepatitis
Hepatocellular carcinoma
Acute cholecystitis
Gallstones
Biliary colic
Acute pancreatitis
Pancreatic cancer
Congenital gastrointestinal disorders: Pathology review
Esophageal disorders: Pathology review
Inflammatory bowel disease: Pathology review
GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review
Diverticular disease: Pathology review
Appendicitis: Pathology review
Gastrointestinal bleeding: Pathology review
Pancreatitis: Pathology review
Colorectal polyps and cancer: Pathology review
Jaundice: Pathology review
Cirrhosis: Pathology review
Gallbladder disorders: Pathology review
Viral hepatitis: Pathology review

Transcript

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Cauda equina syndrome is a condition caused by damage to the bundle of peripheral nerves protruding from the bottom of the spinal cord, called the cauda equina.

The latin words cauda equina mean horse’s tail, which is what early anatomists thought this nerve bundle looked like.

The spinal column is made of individual bones, called vertebrae.

Each vertebra is made of a large anterior portion called the body, and the posterior part called the vertebral arch.

The central cavity between the body and the arch is called the vertebral foramen.

Now the spinal column is made of 33 vertebrae: 7 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 4 coccygeal.

Other than C1 and C2, each two adjacent vertebrae are, separated by an intervertebral disc, which allows for a slight movement of the vertebrae, and acts as a shock absorber.

The sacral and coccygeal vertebrae are fused together to form the sacral bone and coccyx, or tailbone respectively.

Now if you cut the spinal column in half lengthwise you can see that all the vertebral foramina together form the vertebral, or the spinal canal, which is occupied by the spinal cord.

The spinal cord is connected to the brain and travels through the spinal canal to the second lumbar vertebra, where it ends in a cone, called conus medullaris.

There are 31 pairs of nerves originating from the spinal cord called spinal nerves; there are 8 cervical, 12 thoracic, 5 lumbar, 5 sacral and 1 coccygeal.

Each nerve leaves the spinal canal through the corresponding intervertebral foramen, which are openings between two adjacent vertebrae.

Since the spinal cord is shorter than the spinal canal, the nerves of the lumbar, sacral and coccygeal regions have to travel down the spinal canal to reach their corresponding openings, forming a nerve bundle below the spinal cord called the cauda equina.

These nerves carry motor innervation for the genitals, both internal and external anal sphincter, detrusor vesicae, which is a muscle in the bladder that contracts during urination, and muscles of the leg.

They are in charge of the knee and ankle reflexes.

Skin sensations of the legs and pelvis are also carried by these nerves.

Cauda equina syndrome is caused by compression, trauma, or damage to multiple nerves of the cauda equina.

Large lumbar disc herniation is the most common cause of cauda equina syndrome.

And poor posture, traumas, physical activity, and strong rotational movement can cause herniations where the intervertebral disc bulges out and compress the nerves or spinal cord.

This is similar to sciatica, but the herniation is usually larger, and more nerves are compressed, including those that control the bladder and reproductive organs.

Compression can also be caused by spinal stenosis which is the narrowing of the vertebral foramen in the lumbar vertebrae.

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
  5. "Cauda Equina Syndrome" Journal of Pain & Palliative Care Pharmacotherapy (2014)
  6. "Cauda Equina Syndrome Due to Lumbar Disc Herniation: a Review of Literature" Folia Medica (2017)