Introduction to the muscular system

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Introduction to the muscular system

year 1

year 1

Introduction to the immune system
Cytokines
Innate immune system
Complement system
T-cell development
B-cell development
MHC class I and MHC class II molecules
T-cell activation
B-cell activation, differentiation, and contraction
Cell-mediated immunity of CD4 cells
Cell-mediated immunity of natural killer and CD8 cells
Antibody classes
Somatic hypermutation and affinity maturation
VDJ rearrangement
Contracting the immune response and peripheral tolerance
B- and T-cell memory
Anergy, exhaustion, and clonal deletion
Vaccinations
Type I hypersensitivity
Type II hypersensitivity
Type III hypersensitivity
Type IV hypersensitivity
Sepsis
Neonatal sepsis
Abscesses
Food allergy
Anaphylaxis
Asthma
Immune thrombocytopenia
Autoimmune hemolytic anemia
Hemolytic disease of the newborn
Rheumatic heart disease
Myasthenia gravis
Graves disease
Pemphigus vulgaris
Serum sickness
Systemic lupus erythematosus
Poststreptococcal glomerulonephritis
Graft-versus-host disease
Contact dermatitis
X-linked agammaglobulinemia
Selective immunoglobulin A deficiency
Common variable immunodeficiency
IgG subclass deficiency
Hyperimmunoglobulin E syndrome
Isolated primary immunoglobulin M deficiency
Thymic aplasia
DiGeorge syndrome
Severe combined immunodeficiency
Adenosine deaminase deficiency
Ataxia-telangiectasia
Hyper IgM syndrome
Wiskott-Aldrich syndrome
Leukocyte adhesion deficiency
Chediak-Higashi syndrome
Chronic granulomatous disease
Complement deficiency
Hereditary angioedema
Asplenia
Thymoma
Ruptured spleen
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
Glucocorticoids
Non-corticosteroid immunosuppressants and immunotherapies
Skin histology
Skin anatomy and physiology
Hair, skin and nails
Wound healing
Introduction to the skeletal system
Introduction to the muscular system
Bones of the neck
Anatomy clinical correlates: Bones, fascia and muscles of the neck
Bones of the vertebral column
Joints of the vertebral column
Vessels and nerves of the vertebral column
Muscles of the back
Anatomy of the suboccipital region
Anatomy clinical correlates: Bones, joints and muscles of the back
Anatomy of the muscles and nerves of the posterior abdominal wall
Bones of the upper limb
Fascia, vessels and nerves of the upper limb
Anatomy of the brachial plexus
Anatomy of the pectoral and scapular regions
Anatomy of the arm
Muscles of the forearm
Vessels and nerves of the forearm
Muscles of the hand
Anatomy of the sternoclavicular and acromioclavicular joints
Anatomy of the glenohumeral joint
Anatomy of the elbow joint
Anatomy of the radioulnar joints
Joints of the wrist and hand
Anatomy of the axilla
Anatomy clinical correlates: Clavicle and shoulder
Anatomy clinical correlates: Axilla
Anatomy clinical correlates: Arm, elbow and forearm
Anatomy clinical correlates: Wrist and hand
Anatomy clinical correlates: Median, ulnar and radial nerves
Bones of the lower limb
Fascia, vessels and nerves of the lower limb
Anatomy of the anterior and medial thigh
Muscles of the gluteal region and posterior thigh
Vessels and nerves of the gluteal region and posterior thigh
Anatomy of the popliteal fossa
Anatomy of the leg
Anatomy of the foot
Anatomy of the hip joint
Anatomy of the knee joint
Anatomy of the tibiofibular joints
Joints of the ankle and foot
Anatomy clinical correlates: Hip, gluteal region and thigh
Anatomy clinical correlates: Knee
Anatomy clinical correlates: Leg and ankle
Anatomy clinical correlates: Foot
Development of the axial skeleton
Development of the limbs
Development of the muscular system
Bone histology
Cartilage histology
Skeletal muscle histology
Skeletal system anatomy and physiology
Bone remodeling and repair
Cartilage structure and growth
Fibrous, cartilage, and synovial joints
Muscular system anatomy and physiology
Brachial plexus
Neuromuscular junction and motor unit
Sliding filament model of muscle contraction
Slow twitch and fast twitch muscle fibers
Muscle contraction
Muscle spindles and golgi tendon organs
Radial head subluxation (Nursemaid elbow)
Developmental dysplasia of the hip
Legg-Calve-Perthes disease
Slipped capital femoral epiphysis
Transient synovitis
Osgood-Schlatter disease (traction apophysitis)
Rotator cuff tear
Dislocated shoulder
Winged scapula
Thoracic outlet syndrome
Carpal tunnel syndrome
Ulnar claw
Erb-Duchenne palsy
Klumpke paralysis
Iliotibial band syndrome
Unhappy triad
Anterior cruciate ligament injury
Patellar tendon rupture
Meniscus tear
Patellofemoral pain syndrome
Sprained ankle
Achilles tendon rupture
Spondylolysis
Spondylolisthesis
Degenerative disc disease
Spinal disc herniation
Sciatica
Compartment syndrome
Rhabdomyolysis
Osteogenesis imperfecta
Craniosynostosis
Pectus excavatum
Arthrogryposis
Genu valgum
Genu varum
Pigeon toe
Flat feet
Club foot
Cleidocranial dysplasia
Achondroplasia
Osteomyelitis
Bone tumors
Osteochondroma
Chondrosarcoma
Osteoporosis
Osteomalacia and rickets
Osteopetrosis
Paget disease of bone
Osteosclerosis
Lordosis, kyphosis, and scoliosis
Osteoarthritis
Spondylosis
Spinal stenosis
Rheumatoid arthritis
Juvenile idiopathic arthritis
Gout
Calcium pyrophosphate deposition disease (pseudogout)
Psoriatic arthritis
Ankylosing spondylitis
Reactive arthritis
Spondylitis
Septic arthritis
Bursitis
Baker cyst
Muscular dystrophy
Polymyositis
Dermatomyositis
Inclusion body myopathy
Polymyalgia rheumatica
Fibromyalgia
Rhabdomyosarcoma
Lambert-Eaton myasthenic syndrome
Sjogren syndrome
Mixed connective tissue disease
Antiphospholipid syndrome
Raynaud phenomenon
Scleroderma
Back pain: Pathology review
Rheumatoid arthritis and osteoarthritis: Pathology review
Seronegative and septic arthritis: Pathology review
Gout and pseudogout: Pathology review
Systemic lupus erythematosus (SLE): Pathology review
Scleroderma: Pathology review
Sjogren syndrome: Pathology review
Bone disorders: Pathology review
Bone tumors: Pathology review
Myalgias and myositis: Pathology review
Neuromuscular junction disorders: Pathology review
Muscular dystrophies and mitochondrial myopathies: Pathology review
Pediatric musculoskeletal disorders: Pathology review
Acetaminophen (Paracetamol)
Non-steroidal anti-inflammatory drugs
Opioid agonists, mixed agonist-antagonists and partial agonists
Antigout medications
Osteoporosis medications
Fever of unknown origin: Clinical
Infective endocarditis: Clinical
Pneumonia: Clinical
Tuberculosis: Pathology review
Diarrhea: Clinical
Urinary tract infections: Clinical
Meningitis, encephalitis and brain abscesses: Clinical
Bites and stings: Clinical
Skin and soft tissue infections: Clinical
Protein synthesis inhibitors: Aminoglycosides
Antimetabolites: Sulfonamides and trimethoprim
Antituberculosis medications
Miscellaneous cell wall synthesis inhibitors
Protein synthesis inhibitors: Tetracyclines
Cell wall synthesis inhibitors: Penicillins
Miscellaneous protein synthesis inhibitors
Cell wall synthesis inhibitors: Cephalosporins
DNA synthesis inhibitors: Metronidazole
DNA synthesis inhibitors: Fluoroquinolones
Herpesvirus medications
Azoles
Echinocandins
Miscellaneous antifungal medications
Anthelmintic medications
Antimalarials
Anti-mite and louse medications
Joint pain: Clinical
Pediatric orthopedic conditions: Clinical
Rheumatoid arthritis: Clinical
Lower back pain: Clinical
Immunodeficiencies: Clinical
Fat-soluble vitamin deficiency and toxicity: Pathology review
Water-soluble vitamin deficiency and toxicity: B1-B7: Pathology review
Zinc deficiency and protein-energy malnutrition: Pathology review
Viral hepatitis: Clinical
HIV and AIDS: Pathology review
Integrase and entry inhibitors
Nucleoside reverse transcriptase inhibitors (NRTIs)
Protease inhibitors
Hepatitis medications
Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Neuraminidase inhibitors
Seronegative arthritis: Clinical
Systemic lupus erythematosus (SLE): Clinical
Sjogren syndrome: Clinical
Inflammatory myopathies: Clinical
Vasculitis: Clinical
Preoperative evaluation: Clinical
Postoperative evaluation: Clinical
General anesthetics
Local anesthetics
Neuromuscular blockers
Laxatives and cathartics
Anticoagulants: Heparin
Anticoagulants: Warfarin
Anticoagulants: Direct factor inhibitors
Antiplatelet medications
Insulins
Traumatic brain injury: Clinical
Neck trauma: Clinical
Chest trauma: Clinical
Abdominal trauma: Clinical
Anatomy of the vertebral canal
Anatomy of the descending spinal cord pathways
Anatomy of the ascending spinal cord pathways
Anatomy clinical correlates: Vertebral canal
Anatomy clinical correlates: Spinal cord pathways
Superficial structures of the neck: Posterior triangle
Superficial structures of the neck: Cervical plexus
Superficial structures of the neck: Anterior triangle
Deep structures of the neck: Prevertebral muscles
Anatomy of the thyroid and parathyroid glands
Anatomy of the larynx and trachea
Anatomy of the pharynx and esophagus
Anatomy of the lymphatics of the neck
Deep structures of the neck: Root of the neck
Fascia and spaces of the neck
Anatomy clinical correlates: Vessels, nerves and lymphatics of the neck
Anatomy clinical correlates: Viscera of the neck
Introduction to pharmacology
Enzyme function
Pharmacodynamics: Drug-receptor interactions
Pharmacodynamics: Agonist, partial agonist and antagonist
Pharmacodynamics: Desensitization and tolerance
Pharmacokinetics: Drug absorption and distribution
Pharmacokinetics: Drug metabolism
Pharmacokinetics: Drug elimination and clearance
Drug administration and dosing regimens
Mechanisms of antibiotic resistance

Transcript

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The human body consists of hundreds of muscles, which come in all different shapes and sizes. Each muscle’s particular structure allows it to perform a specific function.

The muscles are attached to bones or other tissues, to help us maintain position, perform movements and even protect some organs.

Ok, now muscle tissue is made up of contractile cells, often called muscle fibers. Muscle tissue can be grouped into 3 types; skeletal, cardiac and smooth muscle.

Skeletal muscles connect to the skeleton and other structures like the eyes to help with movement and stability of the body.

These muscles are voluntary, meaning that we have active control of them to perform movements, like flexing your elbow.

Cardiac muscle is the muscle tissue that makes up the walls of the heart. These muscles contract in a rhythmic way to pump blood to the whole body and they are involuntary meaning that we can’t consciously control this type of muscle.

Lastly, is smooth muscle, which mainly lies in the walls of blood vessels and hollow organs. In blood vessels, smooth muscle helps contract the vessel walls to alter their diameter, which helps control blood flow.

In hollow organs, smooth muscles perform rhythmic contractions called peristaltic contractions, which moves the contents of these organs in one direction, like food in the stomach or small intestine.

Smooth muscle is also under involuntary control. Alright, now muscles come in a variety of shapes that help serve their specific functions.

For example, a flat muscle has parallel fibers, and often has a flat sheet-like tendon called an aponeurosis - as is the case for the external oblique muscle covering the abdomen.

Next is a quadrate muscle, which describes a square muscle with four equal sides. An example of a quadrate muscle is the famous six pack, anatomically called the rectus abdominis, which is a long paired muscle that is divided into square-like portions by bands of connective tissue.

Pennate muscles, on the other hand, have their fibers attaching obliquely to a tendon. These muscles can be grouped into unipennate, bipennate or multipennate muscles depending on the relationship between the muscle fascicles and the tendon.

Unipennate muscle fibers go in one direction, and merge on one side of its tendon, like the extensor digitorum longus muscle in the leg.

Bipennate muscles look more like a feather, having oblique fibers on both sides of the tendon, like the rectus femoris of the anterior thigh.

And multipennate muscles have fascicles in different directions, attaching to a branched central tendon, like the deltoid muscle, covering the shoulder.

Next are fusiform muscles, which have a thick muscle belly that becomes tapered at both ends. An example of a fusiform muscle would be the biceps brachii.

Speaking of bi-ceps brachii, multiheaded or multibellied muscles have more than one head of attachment or more than one contractile belly.

Both the biceps brachii and triceps brachii muscles, have two and three fusiform heads, respectively, and thus could also be referred to as multiheaded.

Examples of multibellied muscles include the gastrocnemius muscle in the leg, or the digastric muscle under the jaw which both have two bellies.

Next up are the convergent muscles, which are large muscles that arise from multiple points, but their fibers converge to insert into a single point.

A good example is the pectoralis major muscle of the anterior chest wall. This muscle arises from the sternum, ribs, and clavicle, but inserts into a single spot on the humerus.

Lastly, are circular or sphincteral muscles, which are indeed shaped like a circle. Typically, these muscles surround a body opening, and their circular shape causes constriction of the opening during contraction.

For example, the orbicularis oris surrounds the mouth and when contracted, it helps constrict the oral opening, seen when puckering your lips when whistling.

Okay, now let’s take a deep breath and have a quick quiz! Can you identify the shapes of these muscles? Alright, now muscles attach to different body parts, including bones, cartilage, skin or even other muscles.

For example, many facial muscles attach to the skin of the face, which allows facial muscles to move the skin of the face to produce facial expressions like smiling.

Now, every muscle arises from a point, called the origin, and inserts into a point, called the insertion. Typically, the origin is proximal meaning that it is closer to the trunk of the body.

Key Takeaways

Humans' muscular system consists of hundreds of muscles that carry out many different functions. It is made up of skeletal muscles, which are voluntary muscles that we can control, and smooth muscles, which are involuntary muscles that we cannot control. Skeletal muscles are attached to bones by tendons, and when they contract, they pull on the bones and move the body. Smooth muscles line the walls of blood vessels and organs such as the stomach and intestines, and they contract to move substances through these vessels or organs.

Sources

  1. "Clinically Oriented Anatomy" Lippincott Williams & Wilkins (2013)
  2. "Atlas of Human Anatomy" Saunders/Elsevier (2014)
  3. "Anatomy, Bone Markings" StatPearls (2020 Jan)