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Summary of Primary sclerosing cholangitis
Primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a disease of the bile ducts that causes inflammation and obliterative fibrosis of bile ducts inside and/or outside of the liver. This pathological process impedes the flow of bile to the intestines and can ultimately lead to cirrhosis of the liver, liver failure, and other complications, including but not limited to bile duct and liver cancer. The underlying cause of the inflammation remains unknown, but elements of autoimmunity and microbial dysbiosis are suggested by the fact that approximately 75% of those with PSC also have inflammatory bowel disease (IBD), most often ulcerative colitis. The most definitive treatment for PSC is liver transplantation.
Flashcards on Primary sclerosing cholangitis
Primary sclerosing cholangitis
9 flashcards
Preview
Primary sclerosing cholangitis is a liver disorder that involves inflammation and "onion skin" fibrosis of bile ducts.
Questions on Primary sclerosing cholangitis
Primary sclerosing cholangitis
USMLE® Step 1 style questions
4 questions
Primary sclerosing cholangitis
USMLE® Step 2 style questions
2 questions
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A 40-year-old woman comes into the emergency department because of increasing fatigue over the past two weeks. She reports feeling ill a few weeks ago with fever, chills, and abdominal pain. Her temperature is 37.9°C (100.2°F), pulse is 75/min, respirations are 15/min, and blood pressure is 120/85 mm Hg. Physical exam shows no abnormalities. Serum aminotransferase concentration is 290 U/L, and serum alkaline phosphatase is 100 U/L. Cholangiography shows multifocal stricturing and dilation of both the intrahepatic and extrahepatic bile ducts. Which of the following may also be associated?