Reviewed by Rishi Desai, MD, MPH
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Rapidly progressive glomerulonephritis
Rapidly progressive glomerulonephritis is a renal syndrome characterized by a rapid loss of renal function (usually a 50% decline in the glomerular filtration rate within 3 months), with characteristic glomerular crescent formation (crescent-shaped scars) seen in 50-75% of glomeruli on renal biopsies. If untreated, progression to acute renal failure and death occurs within months. RPGN is associated with an underlying disease such as goodpasture syndrome, systemic lupus erythematosus or granulomatosis with polyangiitis.
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