Skeletal system anatomy and physiology

Last updated: June 19, 2025

Skeletal system anatomy and physiology

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Introduction to the muscular system
Introduction to the skeletal system
Anatomy of the muscles and nerves of the posterior abdominal wall
Anatomy of the suboccipital region
Bones of the vertebral column
Joints of the vertebral column
Muscles of the back
Vessels and nerves of the vertebral column
Anatomy clinical correlates: Bones, joints and muscles of the back
Anatomy of the anterior and medial thigh
Anatomy of the foot
Anatomy of the hip joint
Anatomy of the knee joint
Anatomy of the leg
Anatomy of the popliteal fossa
Anatomy of the tibiofibular joints
Bones of the lower limb
Joints of the ankle and foot
Muscles of the gluteal region and posterior thigh
Vessels and nerves of the gluteal region and posterior thigh
Anatomy clinical correlates: Foot
Anatomy clinical correlates: Hip, gluteal region and thigh
Anatomy clinical correlates: Knee
Anatomy clinical correlates: Leg and ankle
Bones of the neck
Anatomy clinical correlates: Bones, fascia and muscles of the neck
Anatomy of the arm
Anatomy of the axilla
Anatomy of the brachial plexus
Anatomy of the elbow joint
Anatomy of the glenohumeral joint
Anatomy of the pectoral and scapular regions
Anatomy of the radioulnar joints
Anatomy of the sternoclavicular and acromioclavicular joints
Bones of the upper limb
Fascia, vessels and nerves of the upper limb
Joints of the wrist and hand
Muscles of the forearm
Muscles of the hand
Vessels and nerves of the forearm
Vessels and nerves of the hand
Anatomy clinical correlates: Arm, elbow and forearm
Anatomy clinical correlates: Axilla
Anatomy clinical correlates: Clavicle and shoulder
Anatomy clinical correlates: Median, ulnar and radial nerves
Anatomy clinical correlates: Wrist and hand
Development of the axial skeleton
Development of the limbs
Development of the muscular system
Bone histology
Cartilage histology
Skeletal muscle histology
Achondroplasia
Arthrogryposis
Cleidocranial dysplasia
Club foot
Craniosynostosis
Developmental dysplasia of the hip
Flat feet
Genu valgum
Genu varum
Mitochondrial myopathy
Muscular dystrophy
Osteogenesis imperfecta
Pectus excavatum
Pigeon toe
Degenerative disc disease
Legg-Calve-Perthes disease
Osgood-Schlatter disease (traction apophysitis)
Osteomalacia and rickets
Osteopetrosis
Osteoporosis
Osteosclerosis
Paget disease of bone
Spinal disc herniation
Spinal stenosis
Spondylolisthesis
Spondylolysis
Spondylosis
Calcium pyrophosphate deposition disease (pseudogout)
Gout
Osteoarthritis
Compartment syndrome
Rhabdomyolysis
Ankylosing spondylitis
Antiphospholipid syndrome
Dermatomyositis
Juvenile idiopathic arthritis
Limited systemic sclerosis (CREST syndrome)
Mixed connective tissue disease
Polymyositis
Psoriatic arthritis
Raynaud phenomenon
Reactive arthritis
Rheumatoid arthritis
Scleroderma
Sjogren syndrome
Systemic lupus erythematosus
Osteomyelitis
Septic arthritis
Spondylitis
Baker cyst
Bursitis
Iliotibial band syndrome
Inclusion body myopathy
Patellofemoral pain syndrome
Polymyalgia rheumatica
Temporomandibular joint dysfunction
Transient synovitis
Bone tumors
Chondrosarcoma
Osteochondroma
Rhabdomyosarcoma
Fibromyalgia
Lordosis, kyphosis, and scoliosis
Sciatica
Achilles tendon rupture
Anterior cruciate ligament injury
Meniscus tear
Patellar tendon rupture
Slipped capital femoral epiphysis
Sprained ankle
Unhappy triad
Carpal tunnel syndrome
Erb-Duchenne palsy
Klumpke paralysis
Thoracic outlet syndrome
Ulnar claw
Winged scapula
Dislocated shoulder
Radial head subluxation (Nursemaid elbow)
Rotator cuff tear
Bone disorders: Pathology review
Gout and pseudogout: Pathology review
Muscular dystrophies and mitochondrial myopathies: Pathology review
Pediatric musculoskeletal disorders: Pathology review
Myalgias and myositis: Pathology review
Rheumatoid arthritis and osteoarthritis: Pathology review
Scleroderma: Pathology review
Seronegative and septic arthritis: Pathology review
Sjogren syndrome: Pathology review
Systemic lupus erythematosus (SLE): Pathology review
Bone tumors: Pathology review
Back pain: Pathology review
Acetaminophen (Paracetamol)
Glucocorticoids
Non-steroidal anti-inflammatory drugs
Opioid agonists, mixed agonist-antagonists and partial agonists
Non-biologic disease modifying anti-rheumatic drugs (DMARDs)
Antigout medications
Osteoporosis medications
Brachial plexus
Muscle contraction
Muscle spindles and golgi tendon organs
Muscular system anatomy and physiology
Neuromuscular junction and motor unit
Sliding filament model of muscle contraction
Slow twitch and fast twitch muscle fibers
Bone remodeling and repair
Cartilage structure and growth
Fibrous, cartilage, and synovial joints
Skeletal system anatomy and physiology

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Skeletal system anatomy and physiology

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We all have 206 bones, and together they make up the skeleton which gives the body structure, protects important organs like the brain and heart, and allows muscles to facilitate movement.

Without bones you’d be a shapeless, immobile blob.

Normally, the skeleton can be broken down into the axial and the appendicular skeleton.

The axial skeleton consists of bones located along the vertical axis of your body. It contains 80 bones; 22 bones that make up the skull, 33 vertebrae, 24 ribs, and the sternum.

The appendicular skeleton consists of bones in your limbs as well as the bones that attach the limb bones to the axial skeleton, like the pelvis and the scapulae.

The appendicular skeleton is made up of around 126 bones; 4 bones in both shoulders, 6 bones in the arms, 54 bones in the hands, 2 hip bones that form the pelvic girdle, 8 bones in the legs, and 52 bones in the feet.

Now there are 5 types of bones based on their shape - long bones, short bones, flat bones, sesamoid bones, and irregular bones.

Long bones are longer than they are wide, and they’re in the limbs and include the humerus, radius, and ulna in the arms; as well as the metacarpals and phalanges of the hand and fingers.

Long bones also include the femur, tibia, and fibula in the leg as well as metatarsals and phalanges of the feet and toes.

During childhood and adolescence, long bones continues to grow and are the bones that are responsible for your height.

Unlike long bones, the short bones have a similar length and width, and that gives them a round or cube-like appearance. They include the carpal bones of the wrist and tarsal bones of the ankle and their main functions are to support the hand and foot.

Flat bones are thin bones, and some of them are curved. They include bones of the skull, the two shoulder blades or scapulae, sternum, and ribs. Their main job is to serve as armor plating that protects vital organs like the brain, heart, and lungs.

Sesamoid bones, are embedded in tendons and they’re like giant sesame seeds - in shape. Most of these bones can be found in the metacarpal phalangeal joints in the hand and metatarsal phalangeal joints in the feet.

The larger sesamoid bones include the pisiform bone that’s in the wrist, and the patella which is the kneecap.

These bones increase the angle between the bone and the tendon of muscles which gives the muscles more leverage. The sesamoid bones also provide support and protects the tendon from wear and tear.

The last type of bones are the irregular bones which are basically the misfits that don’t fit into any of the previous categories. This includes the the facial bones, the mandible, the vertebrae of the vertebral column, and the sacrum and coccyx.

Now, some bones have surface structures that help them function. For example, bones can have tubercles which are small bumps on the bone that serve as an attachment site for muscles.

A large tubercle is called a tuberosity, and an example is the deltoid tuberosity on the humerus which is where the deltoid muscle attaches.

Holes in the bone that allow blood vessels or nerves to pass through are called foramen. An example of that is the foramen magnum in the occipital bone of the skull, which allows the spinal cord to exit the skull.

Bones can also have canals, which are tunnels within the bone that allow structures like blood vessels or nerves to travel through. An example is the optic canal in the sphenoid bone which allows the optic nerve, to travel from the brain to the eyes.

Another name for a canal is a meatus, like the external auditory meatus of the ear, located in the temporal bone which lets sound pass through to the eardrum.

Some bones have a fossa which is a depression within the bone, where another structure rests. One example is the hypophyseal fossa or sella turcica on the sphenoid bone which is like a tiny seat where the pituitary gland rests.

Also, there are sinuses and cavities, which are empty spaces within a bone or formed by multiple bones coming together. Examples include the nasal cavity which is formed by the maxilla, the nasal bone and palatine bone, as well as the paranasal sinuses, like the maxillary sinus, is located within the maxillary bone.

Key Takeaways

The skeletal system is made up of bones, cartilage, and other connective tissues that provide support and structure to the body. The primary functions of the skeletal system are to protect internal organs, provide support for the body, allow for movement, produce blood cells, and store minerals such as calcium and phosphorus.

Bones are living tissues that are constantly undergoing remodeling, a process in which old bone tissue is broken down and new bone tissue is formed. Bone tissue is composed of cells called osteoblasts, osteocytes, and osteoclasts, as well as a matrix of collagen and mineral salts such as calcium and phosphorus.

Cartilage is a type of connective tissue that provides cushioning and support to joints. It is composed of cells called chondrocytes and a matrix of collagen and proteoglycans. Other connective tissues include ligaments and tendons, which help to connect bones to other bones and muscles, respectively.

Sources

  1. "Medical Physiology" Elsevier (2016)
  2. "Physiology" Elsevier (2017)
  3. "Human Anatomy & Physiology" Pearson (2018)
  4. "Principles of Anatomy and Physiology" Wiley (2014)
  5. "On estimating the directionality distribution in pedicle trabecular bone from micro-CT images" Physiological Measurement (2014)
  6. "Crisóstomo Martínez, 1638-1694 <e1>The Discoverer of Trabecular Bone" Endocrine (2002)
  7. "Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclasts" Archives of Biochemistry and Biophysics (2014)
  8. "Normal bone anatomy and physiology" Clin J Am Soc Nephrol (2008)