RICE

Bacillus cereus Infection Treatment Acronym

Author: Emily Miao, MD
Editor: Alyssa Haag, MD
Editor: Lily Guo, MD
Editor: Kelsey LaFayette, DNP, ARNP, FNP-C
Illustrator: Jannat Day
Modified: Jan 06, 2025

What is Bacillus cereus?

Bacillus cereusor B. cereusis a rod-shaped, toxin-producing gram-positive bacterium that can multiply rapidly at room temperature and create abundant amounts of preformed toxins that can cause gastrointestinal illness. Additionally, B. cereus can form spores, which allow them to survive in extreme temperatures and conditions. It’s often found as a contaminant in various large-batch cooked foods including cooked vegetables and starchy foods, like rice and pasta. These foods become contaminated with B. cereus before being cooked and after being left at room temperature for prolonged periods, meaning the initial contamination typically comes from cross-contamination during handling or cooking. When an individual consumes contaminated food products, they may experience one of two types of food poisoning syndromes: predominantly diarrheal symptoms or a predominantly upper gastrointestinal syndrome characterized by nausea and vomiting without diarrhea. Individuals may also experience constitutional symptoms such as fever, malaise, and fatigue. 

Fried rice syndrome refers to food poisoning caused by foods contaminated with B. cereus bacteria. It received its name from some early cases of food poisoning linked to leftover rice or cooked rice that was not refrigerated properly and later used to make rice-based dishes at restaurants. Of note, it’s important to remember that this illness is not only linked to rice. 

Individuals with severe food poisoning symptoms should immediately seek medical attention for appropriate treatment. To prevent food poisoning, it is important to avoid eating foods that may have been left at room temperature, which falls in the danger zone (i.e., a temperature zone from 40°F to 140°F, which allows bacteria to multiply rapidly). Therefore, when in doubt, throw the leftover foods out! 

An infographic detailing the Bacillus cereus infection treatment acronym, RICE.

What is RICE?

RICE is an acronym that helps clinicians remember some of the treatment options for food poisoning/infection caused by B. cereus 

What does the “R” in RICE mean?

The “R” in RICE stands for rest. Individuals with food poisoning should rest and drink plenty of fluids, as tolerated, to prevent dehydration. Resting and limiting strenuous physical activity can help the body fight infection and prevent dehydration. 

What does the “I” in RICE mean?

The “I” in RICE stands for intravenous (IV) antibiotics used for severe cases of infection. While most cases of food poisoning caused by B. cereus infections are self-limiting and do not require antibiotics, in some instances antibiotics are indicated. For example, in severely immunocompromised individuals (e.g., history of organ transplantation with chronic immunosuppressant use), intravenous antibiotics may be used. Further, B. cereus infections of the bloodstream (i.e., bacteremia), heart (i.e., endocarditis), central nervous system (i.e., meningitis), and eyes (i.e., endophthalmitis), may also require intravenous antibiotic therapy. Most B. cereus isolates are inherently resistant to beta-lactamases, including penicillin and cephalosporins. For severe B. cereus systemic infections, vancomycin is the drug of choice. Alternative agents include carbapenems, fluoroquinolones, and aminoglycosides. 

What does the “C” in RICE mean?

The “C” in RICE stands for cool compresses used for fevers. Individuals can place ice cubes in a plastic bag or run a washcloth under cold water and apply it to the skin for up to 15-20 minutes at a time. Additionally, medications such as acetaminophen and ibuprofen can also reduce fevers. 

What does the “E” in RICE mean?

The “E” in RICE stands for electrolyte replacement. Since individuals will experience upper or lower gastrointestinal symptoms, they must receive enough fluids and electrolyte replacement to prevent dehydration and metabolic derangements. For example, oral rehydration solutions (e.g., a mixture of fluids and salts) and foods that contain salt (e.g., saltine crackers) can help replace lost electrolytes (e.g., sodium). 

What are the most important facts to know about the RICE acronym?

Bacillus cereus is a rod-shaped, toxin-producing gram-positive bacteria that can multiply rapidly at room temperature and produce toxins, causing a gastrointestinal illness. B. cereus is often found as a contaminant in a variety of large batch cooked foods including cooked vegetables and starchy foods, like rice and pasta. These foods become contaminated with B. cereus before being cooked and when left at room temperature for prolonged periods of time. Proper handwashing and food safety measures can help prevent cross contamination. RICE is an acronym that helps clinicians remember some of the treatment options for food poisoning/infection caused by B. cereus. Treatment includes rest, intravenous antibiotics for severe infections, cool compresses for fevers, and electrolyte replacement to prevent dehydration 

References


Fox D, Mathur A, Xue Y, et al. Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome. Nat Commun. 2020;11(1):760. Published 2020 Feb 6. doi:10.1038/s41467-020-14534-3 


Hölzel CS, Tetens JL, Schwaiger K. Unraveling the role of vegetables in spreading antimicrobial-resistant bacteria: A need for quantitative risk assessment. Foodborne Pathog Dis. 2018;15(11):671-688. doi:10.1089/fpd.2018.2501


John S, Neary J, Lee CH. Invasive Bacillus cereus infection in a renal transplant patient: A case report and review. Can J Infect Dis Med Microbiol. 2012;23(4):e109-e110. doi:10.1155/2012/461020 


National Institute of Diabetes and Digestive and Kidney Diseases. Treatment for food poisoning. https://www.niddk.nih.gov/health-information/digestive-diseases/food-poisoning/treatment. Accessed May 11, 2024.  


Thein CC, Trinidad RM, Pavlin BI. A large foodborne outbreak on a small Pacific island. Pac Health Dialog. 2010;16(1):75-80.