ECG basics

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ECG basics

All PBL

All PBL

Iron deficiency anemia
Sickle cell disease (NORD)
Cardiac preload
Cardiac afterload
Preeclampsia & eclampsia
Pregnancy
Liver anatomy and physiology
Hemochromatosis
Anemia of chronic disease
Lesch-Nyhan syndrome
Gout and pseudogout: Pathology review
Nucleotide metabolism
Gout
Jaundice
Jaundice: Clinical
Jaundice: Pathology review
Innate immune system
Introduction to the immune system
T-cell development
B-cell development
Respiratory system anatomy and physiology
Renal system anatomy and physiology
Glomerular filtration
Loop of Henle
Proximal convoluted tubule
Distal convoluted tubule
Phosphate, calcium and magnesium homeostasis
The role of the kidney in acid-base balance
Buffering and Henderson-Hasselbalch equation
Physiologic pH and buffers
Blood groups and transfusions
Blood pressure, blood flow, and resistance
Resistance to blood flow
Blood components
Inflammation
Cell wall synthesis inhibitors: Penicillins
Miscellaneous cell wall synthesis inhibitors
Bone histology
Parathyroid hormone
Pediatric bone and joint infections: Clinical
Cholesterol metabolism
Hypercholesterolemia: Clinical
Miscellaneous lipid-lowering medications
Gallbladder disorders: Pathology review
Gallstones
Non-steroidal anti-inflammatory drugs
Acetaminophen (Paracetamol)
Renal failure: Pathology review
Kidney stones: Pathology review
Atherosclerosis and arteriosclerosis: Pathology review
Arterial disease
Peripheral artery disease: Pathology review
Plasmodium species (Malaria)
Body temperature regulation (thermoregulation)
Ectoderm
Renin-angiotensin-aldosterone system
Body fluid compartments
Regulation of renal blood flow
Movement of water between body compartments
Fever of unknown origin: Clinical
Antimalarials
Stages of labor
Development of the placenta
Inheritance patterns
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Protein synthesis inhibitors: Aminoglycosides
Renal clearance
Osmoregulation
Neuron action potential
Resting membrane potential
Excitability and refractory periods
Ascending and descending spinal tracts
Muscle spindles and golgi tendon organs
Anatomy and physiology of the ear
Auditory transduction and pathways
Nervous system anatomy and physiology
Blood brain barrier
Cerebrospinal fluid
Pyramidal and extrapyramidal tracts
Spinal cord reflexes
Somatosensory pathways
Somatosensory receptors
Vestibular transduction
Brachial plexus
Hyperplasia and hypertrophy
Atrophy, aplasia, and hypoplasia
Metaplasia and dysplasia
Necrosis and apoptosis
Oncogenes and tumor suppressor genes
Sympathetic nervous system
Adrenergic receptors
Parasympathetic nervous system
Cholinergic receptors
Development of the axial skeleton
Development of the nervous system
Anatomy and physiology of the female reproductive system
Menstrual cycle
Estrogen and progesterone
Oxytocin and prolactin
Spina bifida
Angina pectoris
Coronary artery disease: Clinical
Shock
Ischemia
ECG cardiac infarction and ischemia
Type I hypersensitivity
Asthma
Breathing cycle and regulation
Pulmonary corticosteroids and mast cell inhibitors
Cystic fibrosis: Pathology review
Cystic fibrosis: Clinical
Gardnerella vaginalis (Bacterial vaginosis)
Breastfeeding
Pneumonia: Pathology review
Pneumonia
Development of the respiratory system
Isolated primary immunoglobulin M deficiency
Primary ciliary dyskinesia
Anti-tumor antibiotics
Idiopathic intracranial hypertension
Stroke: Clinical
Ischemic stroke
ACE inhibitors, ARBs and direct renin inhibitors
Hypertension: Clinical
Hypertension
Anatomy of the eye
Anatomy and physiology of the eye
Cranial nerves
Cranial nerve pathways
Cranial nerves rap
ECG basics
ECG axis
Deep vein thrombosis
Pulmonary embolism
Factor V Leiden
Coagulation (secondary hemostasis)
Role of Vitamin K in coagulation
Coagulation disorders: Pathology review
Mixed platelet and coagulation disorders: Pathology review
Breast cancer: Clinical
Breast cancer
Human papillomavirus
Cervical cancer: Clinical
MEN syndromes: Clinical
Multiple endocrine neoplasia: Pathology review
Multiple endocrine neoplasia
DNA alkylating medications
Synthesis of adrenocortical hormones
Endocrine system anatomy and physiology
Pleural effusion
Pleural effusion: Clinical
Bone remodeling and repair
Paget disease of bone
Thyroid hormones
Skin cancer: Clinical
Ventilation-perfusion ratios and V/Q mismatch
Ventilation
Gastrointestinal system anatomy and physiology
Gastrointestinal hormones
Enteric nervous system
Gastric motility
Peptic ulcer
Diverticulosis and diverticulitis
Crohn disease
Irritable bowel syndrome
Ulcerative colitis
Acute cholecystitis
Laxatives and cathartics
Abdominal pain: Clinical
Polycystic kidney disease
Pancreatic secretion
Bile secretion and enterohepatic circulation
Cholestatic liver disease
Malabsorption syndromes: Pathology review
Chronic kidney disease
Chronic kidney disease: Clinical
Potter sequence
Inflammatory bowel disease: Clinical
Inflammatory bowel disease: Pathology review
Gestational diabetes
Herpesvirus medications
Herpes simplex virus
Congenital TORCH infections: Pathology review
Abnormal labor: Clinical
Gestational hypertension
Hypertensive disorders of pregnancy: Clinical
Complications during pregnancy: Pathology review
Routine prenatal care: Clinical
Placenta previa
Placental abruption
Streptococcus agalactiae (Group B Strep)
Varicella zoster virus
Anatomy of the heart
Valvular heart disease: Pathology review
Valvular heart disease: Clinical
Normal heart sounds
Anatomy clinical correlates: Heart
Abnormal heart sounds
Rheumatic heart disease
Heart blocks: Pathology review
Cardiac conduction system
Pulmonary valve disease
Mitral valve disease
Infective endocarditis: Clinical
Cardiac cycle
Tricuspid valve disease
Aortic valve disease
Cardiovascular system anatomy and physiology
Post-traumatic stress disorder
Cortisol
Membranous nephropathy
IgA nephropathy (NORD)
Nephritic and nephrotic syndromes: Clinical
Nephrotic syndromes: Pathology review

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An electrocardiogram is also known as an ECG; the Dutch and German version of the word, elektrokardiogram, is shortened to EKG. It is a tool used to visualize, or “gram,” the electricity, or “electro,” that flows through the heart, or “cardio.” Specifically, a 12-lead ECG tracing shows how the depolarization wave, which is a wave of positive charge, moves during each heartbeat, by providing the perspectives of different sets of electrodes. This particular set of electrodes is called lead II; one electrode is placed on the right arm and the other on the left leg. Essentially, when the wave’s moving toward the left leg electrode, you get a positive deflection. This big, positive deflection corresponds to the wave moving down the septum.

To understand the basics, let’s start with an example of how we can look at the heart with only one pair of electrodes: a positive and a negative one. These electrodes detect the charge on the outside of the cell. Remember, at rest, cells are negatively charged relative to the slightly positive outside environment; let’s make these cells red. When they depolarize, the cells become positively charged, and leave a slightly negative charge in the outside environment; let’s make these cells green. Now, if we freeze this “wave of depolarization” as it’s moving through the cells, half of the cells are negative, or depolarized, and half are positive and resting; therefore, there’s a difference of charge across this set of cells. You can think of the charge difference as being a dipole, because there are two electrical poles. We can draw this dipole out as an arrow, or vector, pointing towards the positive charge. Remember, the electrodes detect charge on the outside of the cell, so this points toward where the positive charge is, outside.

Now, if there’s a dipole vector pointing toward the positive electrode, then the ECG tracing shows it as a positive deflection; the bigger the dipole is, the bigger the deflection is. If we unpause this, then everything becomes depolarized. Since there’s no difference in charge, there’s no dipole, and thus no deflection. Moments later, a wave of repolarization goes through, and the cells become negative once again. Pausing halfway through again, now the vector dipole goes in the opposite direction, and faces the negative electrode; this means that there will be a negative ECG tracing. Again, the bigger the dipole is, the bigger the negative deflection is. Even though it’d be nice if the depolarization wave lined up perfectly with the electrodes, usually that’s not the case. So, we simply look at the vector component that is parallel to that electrode. For example, let’s say that the depolarization happened this way, at an angle; then, we’d simply break the vector into two parts. The one we care about is the one that’s going towards the positive electrode, which causes a deflection, even though it’s a slightly smaller deflection than previously. In other words, the size of the deflection on the ECG tracing always corresponds to the magnitude, or size, of the dipole in the direction of the electrode. The perpendicular component isn’t pointing at the electrodes, so it doesn’t cause any deflection. In fact, if there’s a depolarization wave that goes straight up, perpendicular to the positive and negative electrodes, there would be no deflection!

In a standard ECG, there are 10 electrodes: four limb electrodes, with one each on the left arm, right arm, left leg, and right leg; and six precordial electrodes, V1 through V6, that wrap around the chest. The right leg electrode is usually used as a neutral lead. The heart is a three-dimensional organ, so V1 through V6 line up in the transverse, or horizontal, plane of the heart. Each electrode is set up to detect any wave of positive charge coming towards it. These are collectively called the chest leads.

Sources

  1. "Medical Physiology" Elsevier (2016)
  2. "Physiology" Elsevier (2017)
  3. "Human Anatomy & Physiology" Pearson (2017)
  4. "Principles of Anatomy and Physiology" Wiley (2014)
  5. "Screening for Cardiovascular Disease Risk With Electrocardiography" JAMA (2018)
  6. "Screening for Coronary Heart Disease With Electrocardiography: U.S. Preventive Services Task Force Recommendation Statement" Annals of Internal Medicine (2012)
  7. "Activation of the Interventricular Septum" Circulation Research (1955)