Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a rare disease that involves the abnormal proliferation of Langerhans cells in the skin. Langerhans cells are dendritic cells that arise from bone marrow and migrate to skin. People with LCH can present with lytic bone lesions, skin lesions, weight loss, fever, skin lesions, hepatosplenomegaly, and bone pain.