Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. Protein C deficiency is associated with an increased incidence of venous thromboembolism. The main function of
is its anticoagulant property as an inhibitor of coagulation factors
VIII. A deficiency results in a loss of the normal cleaving of Factors Va and VIIIa. Patients with protein C deficiency are at an increased risk of developing skin necrosis while on warfarin
. Protein C has a short half life (8 hour) compared with other vitamin K
-dependent factors and therefore is rapidly depleted with warfarin initiation, resulting in a transient hypercoagulable state.