Osmosis video - Protein C deficiency

Protein C deficiency is a rare genetic trait that results from a lack of functional protein C. Protein C is a naturally occurring anticoagulant that helps to prevent excessive blood clotting by inhibiting coagulation factors V and VIII. So, its deficiency will predispose people to thrombotic disease and an increased incidence of venous thromboembolism. Furthermore, people with protein C deficiency are at an increased risk of developing skin necrosis while on warfarin. Treatment for protein C deficiency typically involves anticoagulants to prevent the formation of blood clots. In some cases, replacement therapy with protein C concentrates may be used.