Monoclonal gammopathy of undetermined significance

Monoclonal gammopathy of undetermined significance (MGUS), is a condition in which there is a single paraprotein in blood without any evidence of other diseases or abnormal conditions.

MGUS is considered to be a "premalignant" condition and can eventually develop into multiple myeloma or a lymphoproliferative disorder. Treatment for MGUS is generally not necessary, as the condition is generally considered to be benign. However, regular monitoring is important.