Sleep apnea

Sleep apnea

Cardiothoracic Disease

Cardiothoracic Disease

Respiratory system anatomy and physiology
Lung volumes and capacities
Anatomic and physiologic dead space
Ventilation
Alveolar gas equation
Compliance of lungs and chest wall
Combined pressure-volume curves for the lung and chest wall
Alveolar surface tension and surfactant
Airflow, pressure, and resistance
Breathing cycle
Breathing control
Pulmonary chemoreceptors and mechanoreceptors
Ideal (general) gas law
Boyle's law
Dalton's law
Henry's law
Fick's laws of diffusion
Graham's law
Diffusion-limited and perfusion-limited gas exchange
Hypoxia
Oxygen binding capacity and oxygen content
Oxygen-hemoglobin dissociation curve
Erythropoietin
Carbon dioxide transport in blood
Regulation of pulmonary blood flow
Zones of pulmonary blood flow
Pulmonary shunts
Ventilation-perfusion ratios and V/Q mismatch
Pulmonary changes during exercise
Pulmonary changes at high altitude and altitude sickness
Diffuse parenchymal lung disease: Clinical
Restrictive lung diseases: Pathology review
Restrictive lung diseases
Idiopathic pulmonary fibrosis
Sarcoidosis
Lung cancer: Clinical
Lung cancer and mesothelioma: Pathology review
Mesothelioma
Cardiovascular system anatomy and physiology
Lymphatic system anatomy and physiology
Cardiac cycle
Normal heart sounds
Abnormal heart sounds
Blood pressure, blood flow, and resistance
Resistance to blood flow
Laminar flow and Reynolds number
Compliance of blood vessels
Pressures in the cardiovascular system
Physiological changes during exercise
Cardiovascular changes during hemorrhage
Cardiovascular changes during postural change
Measuring cardiac output (Fick principle)
Cardiac and vascular function curves
Altering cardiac and vascular function curves
Stroke volume, ejection fraction, and cardiac output
Frank-Starling relationship
Pressure-volume loops
Changes in pressure-volume loops
Cardiac work
Cardiac preload
Cardiac afterload
Law of Laplace
Baroreceptors
Renin-angiotensin-aldosterone system
Chemoreceptors
Cardiac conduction system
Action potentials in pacemaker cells
Action potentials in myocytes
Cardiac conduction velocity
Excitability and refractory periods
Cardiac excitation-contraction coupling
Cardiac contractility
Cerebral circulation
Coronary circulation
Control of blood flow circulation
Microcirculation and Starling forces
Cardiomyopathies: Clinical
Cardiomyopathies: Pathology review
Hypertrophic cardiomyopathy
Dilated cardiomyopathy
Restrictive cardiomyopathy
Sleep apnea
Apnea of prematurity
Aortic aneurysms and dissections: Clinical
Aortic dissections and aneurysms: Pathology review
Aortic dissection
Aneurysms
Marfan syndrome
Peripheral vascular disease: Clinical
Peripheral artery disease: Pathology review
Peripheral artery disease
Arterial disease
Deep vein thrombosis
Leg ulcers: Clinical
Chronic venous insufficiency
Thrombophlebitis
Vasculitis: Pathology review
Vasculitis
Kawasaki disease
Behcet's disease
Nutcracker syndrome
Superior mesenteric artery syndrome
Subclavian steal syndrome
Coronary steal syndrome
Lymphedema
ECG basics
ECG normal sinus rhythm
ECG rate and rhythm
ECG intervals
ECG axis
ECG QRS transition
ECG cardiac hypertrophy and enlargement
ECG cardiac infarction and ischemia
Heart blocks: Pathology review
Premature ventricular contraction
Premature atrial contraction
Atrial fibrillation
Atrial flutter
Atrioventricular nodal reentrant tachycardia (AVNRT)
Wolff-Parkinson-White syndrome
Atrioventricular block
Bundle branch block
Long QT syndrome and Torsade de pointes
Ventricular tachycardia
Brugada syndrome
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Class I antiarrhythmics: Sodium channel blockers
Class II antiarrhythmics: Beta blockers
Class III antiarrhythmics: Potassium channel blockers
Class IV antiarrhythmics: Calcium channel blockers and others
Positive inotropic medications
Sympatholytics: Alpha-2 agonists
Adrenergic antagonists: Alpha blockers
Adrenergic antagonists: Beta blockers
Adrenergic antagonists: Presynaptic
cGMP mediated smooth muscle vasodilators
Calcium channel blockers
Heart failure: Clinical
Heart failure: Pathology review
Heart failure
Cor pulmonale
Pulmonary hypertension
Pulmonary edema
Anatomy of the coronary circulation
Asthma: Clinical
Obstructive lung diseases: Pathology review
Asthma
Chronic obstructive pulmonary disease (COPD): Clinical
Chronic bronchitis
Emphysema
Alpha 1-antitrypsin deficiency
Bronchodilators: Beta 2-agonists and muscarinic antagonists
Bronchodilators: Leukotriene antagonists and methylxanthines
Pulmonary corticosteroids and mast cell inhibitors
Non-corticosteroid immunosuppressants and immunotherapies
Cystic fibrosis: Pathology review
Cystic fibrosis
Bronchiectasis
Anatomy of the heart
Anatomy clinical correlates: Heart
Cardiac muscle histology
Marfan syndrome
Ehlers-Danlos syndrome
Arteriole, venule and capillary histology
Cardiac muscle histology
Artery and vein histology
Trachea and bronchi histology
Bronchioles and alveoli histology
Nasal cavity and larynx histology
Coarctation of the aorta
Mitral valve disease
Pulmonary valve disease
Tricuspid valve disease
Aortic valve disease
Ventricular arrhythmias: Pathology review
Supraventricular arrhythmias: Pathology review
Coronary artery disease: Clinical
Atherosclerosis and arteriosclerosis: Pathology review
Coronary artery disease: Pathology review
Arterial disease
Angina pectoris
Unstable angina
Myocardial infarction
Prinzmetal angina
Coronary steal syndrome

Flashcards

Sleep apnea

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Transcript

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Sleep apnea is a sleep disorder which causes irregular breathing and snoring patterns that can ultimately cause apnea, which is where a person momentarily stops breathing altogether. The inability to get restful sleep can also lead to severe exhaustion.

Individuals can have obstructive sleep apnea, central sleep apnea, or features of both. Obstructive sleep apnea is the most common form, and it develops when there’s a blockage of the airways. Now, air has to go from the nose through the nasopharynx into the laryngopharynx, through the larynx and then into the trachea. Somewhere along that path, there might be a blockage in the flow of air.

Allergies might cause swelling in the tissues in the nasopharynx, or there might be swollen adenoid glands or tonsils because of an infection. There might be a severe overbite which pulls the jaw back and blocks the airway. In individuals that are overweight, there could be too much weight in the soft tissues of the neck, which can weigh down the airway especially when a person is lying down.

These problems are most obvious at night because hormonal changes at night cause the muscles around the airway to become slightly less stiff while sleeping. This means that they are less able to keep the airway open, making it more likely to get a bit squashed or obstructed.

Central sleep apnea, on the other hand, refers to the fact that the problem is “central” or related to the central nervous system. This is where the brain intermittently stops making an effort to breathe for 10 to 30 seconds. The apnea can persist for several seconds even after waking up, triggering feelings of panic and further disrupting the sleep cycle.

Central sleep apnea starts with an initial episode of hyperpnea, which is when the brain directs the lungs to start hyperventilating during sleep by increasing the respiratory rate. This rapid breathing causes hypocapnia, a drop in the blood’s carbon dioxide levels.

When the carbon dioxide falls below a certain threshold, the body slips into a state of apnea, making no effort to breathe and taking in no oxygen. This causes the carbon dioxide levels to rise back to normal levels and then, as the apnea persists, they keep rising to a point which is called hypercapnia. The really high carbon dioxide levels trigger hyperpnea again, and the cycle starts all over. Essentially, the respiratory system is going rapidly back and forth between two states, first making no effort to breathe and then hyperventilating, with no in-between.

Key Takeaways

Sleep apnea is a sleep disorder characterized by brief interruptions of breathing during sleep. These apneic events can occur several times an hour and last from a few seconds to minutes. Symptoms include snoring, daytime sleepiness and fatigue, and morning headaches. There are two main types of sleep apnea: obstructive sleep apnea, caused by a physical blockage of the airway, and central sleep apnea, caused by a failure of the brain to properly control breathing. Older age, obesity, and male sex are the strongest risk factors.

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "CURRENT Medical Diagnosis and Treatment 2020" McGraw Hill Professional (2019)
  5. "Meta-analysis: Continuous Positive Airway Pressure Improves Insulin Resistance in Patients with Sleep Apnea without Diabetes" Annals of the American Thoracic Society (2013)
  6. "Obstructive sleep apnoea syndrome and its management" Therapeutic Advances in Chronic Disease (2015)
  7. "Sleep Pathologies in Depression and the Clinical Utility of Polysomnography" The Canadian Journal of Psychiatry (2010)