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|ALPHA-2 ADRENERGIC AGONISTS|
|DRUG NAME||clonidine (Catapres-TTS, Duraclon, Kapvay), guanfacine (Intuniv), methyldopa |
|CLASS||α2 selective adrenergic agonists|
|MECHANISM of ACTION||Stimulate presynaptic α2-adrenergic receptors in the CNS → dilates peripheral blood vessels → lowers peripheral resistance → reduces blood pressure|
|ROUTE(S) of ADMIN|
|CONTRAINDICATIONS & CAUTIONS|
|NURSING CONSIDERATIONS for |
ALPHA-2 ADRENERGIC AGONISTS
|ASSESSMENT & MONITORING||Assess |
Alpha-2 adrenergic agonists are medications that oppose the effects of the sympathetic nervous system, ultimately decreasing smooth muscle contraction.
This triggers the fight or flight response, which results in smooth muscle contraction, in turn leading to an increase in the heart rate and blood pressure, as well as decreasing gastrointestinal motility and urination by contracting the sphincters.
Now if we zoom into this synapse, we can see that some of the norepinephrine turns around and binds to alpha-2 adrenergic receptors.
This inhibits further release of norepinephrine and serves as a mechanism of negative feedback control.
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