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|ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs)|
|DRUG NAME||-sartan: i.e., valsartan (Diovan); losartan (Cozaar); candesartan (Atacand); irbesartan (Avapro)|
|CLASS||Angiotensin II receptor blockers (ARBs)|
|MECHANISM OF ACTION||Prevent angiotensin II from binding to angiotensin II receptors on blood vessels and adrenal glands; decrease aldosterone secretion|
|ROUTE(S) OF ADMINISTRATION||PO|
|CONTRAINDICATIONS AND CAUTIONS|
|NURSING CONSIDERATIONS||Assessment and monitoring|
Angiotensin II receptor blockers or ARBs for short, are a group of medications that help decrease blood pressure and are typically used to treat hypertension or high blood pressure, and heart failure.
Normally, when angiotensin II binds to these receptors on blood vessels, it causes them to constrict, which increases the blood pressure.
On the other hand, in the adrenal glands, angiotensin II stimulates the release of aldosterone, which increases reabsorption of sodium and water in the kidneys.
This results in increased blood volume, which also increases blood pressure. Once ARBs are administered, angiotensin II can’t bind to angiotensin II receptors, which decreases vasoconstriction, as well as aldosterone release by the adrenals.
Angiotensin II receptor blockers (ARBs) are a type of medication used to treat mainly high blood pressure and congestive heart failures. ARBs work by blocking the action of angiotensin II, a hormone that causes blood vessels' smooth muscles to contract. This relaxation of the muscles allows blood vessels to widen and results in a decrease in blood pressure.
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