, also known as gamma-hexachlorocyclohexane
, (γ-HCH), gammaxene
and sometimes incorrectly called benzene hexachloride
(BHC), is an organochlorine chemical variant of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical treatment for lice and scabies. Lindane medications continue to be available in the US, though since 1995 they have been designated "second-line" treatments, meaning they should be prescribed when other "first-line" treatments have failed or cannot be used. Lindane is a neurotoxin that interferes with GABA neurotransmitterfunction by interacting with the GABAA
receptor-chloride channel complex at the picrotoxin binding site. In humans, lindane affects the nervous system
, liver and kidneys, and may well be a carcinogen. It is unclear whether lindane is an endocrine disruptor.