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|DRUG NAME||atovaquone (Mepron), tinidazole (Tindamax), pyrimethamine (Daraprim), benznidazole (Rochagan, Radanil), nitazoxanide, pentamidine (NebuPent)|
|MECHANISM OF ACTION||Block DNA synthesis in protozoa → prevent reproduction → death|
|INDICATIONS||Protozoan infections (e.g., giardiasis, trichomoniasis, intestinal amebiasis)|
|ROUTE(S) OF ADMINISTRATION|
|CONTRAINDICATIONS AND CAUTIONS|
|NURSING CONSIDERATIONS: ANTIPROTOZOALS|
|ASSESSMENT AND MONITORING||Assessment|
The most commonly used antiprotozoals are atovaquone, tinidazole, benznidazole, pyrimethamine, and nitazoxanide, which can be taken orally; as well as pentamidine that can be administered by nebulizer, intramuscularly, or intravenously.
Once administered, antiprotozoals act on protozoa by blocking DNA synthesis, preventing them from reproducing, and ultimately killing them.
In addition, antiprotozoals may often cause gastrointestinal disturbances, such as an unpleasant mouth taste, nausea, vomiting, diarrhea, and cramping.
Moreover, these medications can disrupt the normal intestinal flora, so clients might develop bacterial or fungal superinfections.
Finally, some of these medications can be associated with hematologic abnormalities, such as leukopenia, anemia, or thrombocytopenia; while tinidazole has a boxed warning for increasing the risk of developing malignancy.
Now, antiprotozoals are contraindicated during pregnancy and breastfeeding, while precautions should be taken with children and elderly clients.
In addition, these medications should also be used with caution in clients with hematologic or central nervous system disorders, as well as in those with cardiac, renal, or hepatic disease, and alcoholic beverages should be avoided.
Okay, when caring for a client with giardiasis who has been prescribed tinidazole, first obtain a baseline of your client’s symptoms, such as fatigue, stomach pain and cramping, as well as stool characteristics and frequency.
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