Megaloblastic anemia
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Megaloblastic anemia
PATHO
PATHO
Macrocytic anemia: Pathology review
Anemia: Clinical
Iron deficiency anemia
Non-hemolytic normocytic anemia: Pathology review
Megaloblastic anemia
Sickle cell disease: Clinical
Platelet disorders: Pathology review
Beta-thalassemia
Leukemia: Clinical
Leukemias: Pathology review
Atrial fibrillation
Human herpesvirus 8 (Kaposi sarcoma)
Ovarian germ cell tumors
Epstein-Barr virus (Infectious mononucleosis)
Free radicals and cellular injury
Necrosis and apoptosis
Ischemia
Hypoxia
Amyloidosis
Inflammation
Wound healing
Atrophy, aplasia, and hypoplasia
Hyperplasia and hypertrophy
Metaplasia and dysplasia
Oncogenes and tumor suppressor genes
Thrombosis syndromes (hypercoagulability): Pathology review
Deep vein thrombosis and pulmonary embolism: Pathology review
Antiphospholipid syndrome
Antithrombin III deficiency
Factor V Leiden
Myeloproliferative neoplasms: Clinical
Pulmonary embolism
Microcytic anemia: Pathology review
Iron deficiency anemia
Beta-thalassemia
Alpha-thalassemia
Sideroblastic anemia
Anemia of chronic disease
Lead poisoning
Hemolytic disease of the newborn
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Autoimmune hemolytic anemia
Pyruvate kinase deficiency
Paroxysmal nocturnal hemoglobinuria
Sickle cell disease (NORD)
Hereditary spherocytosis
Aplastic anemia
Fanconi anemia
Megaloblastic anemia
Folate (Vitamin B9) deficiency
Vitamin B12 deficiency
Diamond-Blackfan anemia
Acute intermittent porphyria
Porphyria cutanea tarda
Hemophilia
Vitamin K deficiency
Bernard-Soulier syndrome
Glanzmann's thrombasthenia
Hemolytic-uremic syndrome
Immune thrombocytopenia
Thrombotic thrombocytopenic purpura
Von Willebrand disease
Disseminated intravascular coagulation
Heparin-induced thrombocytopenia
Antithrombin III deficiency
Factor V Leiden
Protein C deficiency
Protein S deficiency
Antiphospholipid syndrome
Hodgkin lymphoma
Non-Hodgkin lymphoma
Chronic leukemia
Acute leukemia
Leukemoid reaction
Myelodysplastic syndromes
Polycythemia vera (NORD)
Myelofibrosis (NORD)
Essential thrombocythemia (NORD)
Langerhans cell histiocytosis
Mastocytosis (NORD)
Multiple myeloma
Monoclonal gammopathy of undetermined significance
Waldenstrom macroglobulinemia
Microcytic anemia: Pathology review
Non-hemolytic normocytic anemia: Pathology review
Intrinsic hemolytic normocytic anemia: Pathology review
Extrinsic hemolytic normocytic anemia: Pathology review
Macrocytic anemia: Pathology review
Heme synthesis disorders: Pathology review
Coagulation disorders: Pathology review
Platelet disorders: Pathology review
Mixed platelet and coagulation disorders: Pathology review
Thrombosis syndromes (hypercoagulability): Pathology review
Lymphomas: Pathology review
Leukemias: Pathology review
Plasma cell disorders: Pathology review
Myeloproliferative disorders: Pathology review
Type IV hypersensitivity
Pneumothorax: Clinical
Flashcards
Megaloblastic anemia
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Questions
USMLE® Step 1 style questions USMLE
0 of 3 complete
A 35-year-old woman presents to her provider’s office for evaluation of fatigue and exercise intolerance that began two months ago. Past medical history is notable for Crohn disease diagnosed eight-years ago. She is taking mesalamine but reports frequent “flare-ups.” The patient consumes 3-4 glasses of wine per week. Her temperature is 36.9°C (98.4°F), blood pressure is 123/76 mmHg, pulse is 75/min, and respiratory rate is 12/min. The patient has conjunctival pallor. Cardiac, pulmonary, and abdominal examinations are non-contributory. Neurological examination reveals decreased proprioception and vibratory sensation in the lower extremities. Complete blood count reveals a hemoglobin of 8.8 g/dL (reference range: 12-16 g/dL) and a mean corpuscular volume (MCV) of 115 µm3 (reference range: 80-100 µm3). Which of the following findings would be most likely present in this patient?
Key Takeaways
Megaloblastic anemia is a type of anemia caused by deficiencies in folic acid (folate) or vitamin B12. Folic acid and vitamin B12 are essential for DNA synthesis, and thus the production of healthy red blood cells. Megaloblastic anemia is characterized by large, nucleated red blood cell precursors which don't divide and produce more red blood cells as normal precursor cells do. Symptoms include fatigue, shortness of breath, and pale skin.