Sleep apnea

29,803views

Sleep apnea

Watch later

Watch later

Cardiovascular system anatomy and physiology
Normal heart sounds
Abnormal heart sounds
Blood pressure, blood flow, and resistance
Measuring cardiac output (Fick principle)
Pressures in the cardiovascular system
Baroreceptors
Chemoreceptors
Renin-angiotensin-aldosterone system
Cardiac contractility
Cardiac conduction system
Myocardial infarction
Angina pectoris
Aortic dissection
Aneurysms
Tricuspid valve disease
Mitral valve disease
Pulmonary valve disease
Aortic valve disease
Hypertrophic cardiomyopathy
Skin anatomy and physiology
Wound healing
Hair, skin and nails
Atopic dermatitis
Psoriasis
Lichen planus
Albinism
Burns
Actinic keratosis
Skin cancer
Endocrine system anatomy and physiology
Thyroid hormones
Cortisol
Synthesis of adrenocortical hormones
Calcitonin
Parathyroid hormone
Vitamin D
Cushing syndrome
Diabetes mellitus
Hyperparathyroidism
Hypoparathyroidism
Hypothyroidism
Hyperthyroidism
Toxic multinodular goiter
Graves disease
Thyroid cancer
Pheochromocytoma
Neuroblastoma
Gastrointestinal system anatomy and physiology
Pancreatic secretion
Liver anatomy and physiology
Bile secretion and enterohepatic circulation
Carbohydrates and sugars
Proteins
Fats and lipids
Prebiotics and probiotics
Vitamins and minerals
Barrett esophagus
Mallory-Weiss syndrome
Gastroesophageal reflux disease (GERD)
Boerhaave syndrome
Peptic ulcer
Gastritis
Colorectal polyps
Ulcerative colitis
Gallstones
Cirrhosis
Non-alcoholic fatty liver disease
Alcohol-associated liver disease
Hemochromatosis
Viral hepatitis
Portal hypertension
Hirschsprung disease
Pyloric stenosis
Oral cancer
Benign liver tumors
Blood components
Coagulation (secondary hemostasis)
Clot retraction and fibrinolysis
Platelet plug formation (primary hemostasis)
Role of Vitamin K in coagulation
Iron deficiency anemia
Alpha-thalassemia
Beta-thalassemia
Anemia of chronic disease
Aplastic anemia
Autoimmune hemolytic anemia
Sickle cell disease (NORD)
Von Willebrand disease
Hemophilia
Acute leukemia
Chronic leukemia
Hodgkin lymphoma
Non-Hodgkin lymphoma
Polycythemia vera (NORD)
Essential thrombocythemia (NORD)
Skeletal system anatomy and physiology
Cartilage structure and growth
Bone remodeling and repair
Fibrous, cartilage, and synovial joints
Rheumatoid arthritis
Gout
Systemic lupus erythematosus
Raynaud phenomenon
Amyloidosis
Scleroderma
Fibromyalgia
Osteoarthritis
Paget disease of bone
Osteoporosis
Legg-Calve-Perthes disease
Osteomalacia and rickets
Osgood-Schlatter disease (traction apophysitis)
Septic arthritis
Osteomyelitis
Lordosis, kyphosis, and scoliosis
Rotator cuff tear
Meniscus tear
Sprained ankle
Compartment syndrome
Bone tumors
Developmental dysplasia of the hip
Nervous system anatomy and physiology
Anatomy and physiology of the eye
Anatomy and physiology of the ear
Neuron action potential
Sympathetic nervous system
Parasympathetic nervous system
Adrenergic receptors
Cholinergic receptors
Cerebellum
Optic pathways and visual fields
Brachial plexus
Seizures and epilepsy
Migraine
Tension headache
Cluster headache
Alzheimer disease
Frontotemporal dementia
Vascular dementia
Dementia with Lewy bodies
Multiple sclerosis
Muscular dystrophy
Bell palsy
Concussion and traumatic brain injury
Cauda equina syndrome
Neurogenic bladder
Parkinson disease
Sciatica
Carpal tunnel syndrome
Eustachian tube dysfunction
Glaucoma
Major depressive disorder
Major depressive disorder with seasonal pattern
Suicide
Bipolar and related disorders
Generalized anxiety disorder
Post-traumatic stress disorder
Schizophrenia
Alcohol use disorder
Tobacco use disorder
Cannabis use disorder
Opioid use disorder
Cocaine use disorder
Cluster A personality disorders
Cluster B personality disorders
Cluster C personality disorders
Autism spectrum disorder
Attention deficit hyperactivity disorder
Learning disability
Delirium
Renal system anatomy and physiology
Movement of water between body compartments
Renal clearance
Osmoregulation
Antidiuretic hormone
Regulation of renal blood flow
Glomerular filtration
Proximal convoluted tubule
Loop of Henle
Potassium homeostasis
Phosphate, calcium and magnesium homeostasis
Sodium homeostasis
The role of the kidney in acid-base balance
Diabetic nephropathy
Lower urinary tract infection
Acute pyelonephritis
Chronic pyelonephritis
Kidney stones
Urinary incontinence
Hydronephrosis
Polycystic kidney disease
Estrogen and progesterone
Menstrual cycle
Menopause
Oxytocin and prolactin
Pregnancy
Anatomy and physiology of the female reproductive system
Anatomy and physiology of the male reproductive system
Testosterone
Development of the reproductive system
Puberty and Tanner staging
Ovarian cyst
Endometriosis
Uterine fibroid
Endometritis
Amenorrhea
Benign prostatic hyperplasia
Pelvic inflammatory disease
Cervical cancer
Endometrial cancer
Breast cancer
Respiratory system anatomy and physiology
Respiratory syncytial virus
Pneumonia
Asthma
Chronic bronchitis
Emphysema
Nasal polyps
Sinusitis
Bacterial epiglottitis
Allergic rhinitis
Upper respiratory tract infection
Laryngitis
Retropharyngeal and peritonsillar abscesses
Pulmonary hypertension
Lung cancer
Mesothelioma
Sleep apnea
Restrictive lung diseases
Vitiligo

Flashcards

Sleep apnea

0 of 7 complete

Transcript

Watch video only

Sleep apnea is a sleep disorder which causes irregular breathing and snoring patterns that can ultimately cause apnea, which is where a person momentarily stops breathing altogether. The inability to get restful sleep can also lead to severe exhaustion.

Individuals can have obstructive sleep apnea, central sleep apnea, or features of both. Obstructive sleep apnea is the most common form, and it develops when there’s a blockage of the airways. Now, air has to go from the nose through the nasopharynx into the laryngopharynx, through the larynx and then into the trachea. Somewhere along that path, there might be a blockage in the flow of air.

Allergies might cause swelling in the tissues in the nasopharynx, or there might be swollen adenoid glands or tonsils because of an infection. There might be a severe overbite which pulls the jaw back and blocks the airway. In individuals that are overweight, there could be too much weight in the soft tissues of the neck, which can weigh down the airway especially when a person is lying down.

These problems are most obvious at night because hormonal changes at night cause the muscles around the airway to become slightly less stiff while sleeping. This means that they are less able to keep the airway open, making it more likely to get a bit squashed or obstructed.

Central sleep apnea, on the other hand, refers to the fact that the problem is “central” or related to the central nervous system. This is where the brain intermittently stops making an effort to breathe for 10 to 30 seconds. The apnea can persist for several seconds even after waking up, triggering feelings of panic and further disrupting the sleep cycle.

Central sleep apnea starts with an initial episode of hyperpnea, which is when the brain directs the lungs to start hyperventilating during sleep by increasing the respiratory rate. This rapid breathing causes hypocapnia, a drop in the blood’s carbon dioxide levels.

When the carbon dioxide falls below a certain threshold, the body slips into a state of apnea, making no effort to breathe and taking in no oxygen. This causes the carbon dioxide levels to rise back to normal levels and then, as the apnea persists, they keep rising to a point which is called hypercapnia. The really high carbon dioxide levels trigger hyperpnea again, and the cycle starts all over. Essentially, the respiratory system is going rapidly back and forth between two states, first making no effort to breathe and then hyperventilating, with no in-between.

Key Takeaways

Sleep apnea is a sleep disorder characterized by brief interruptions of breathing during sleep. These apneic events can occur several times an hour and last from a few seconds to minutes. Symptoms include snoring, daytime sleepiness and fatigue, and morning headaches. There are two main types of sleep apnea: obstructive sleep apnea, caused by a physical blockage of the airway, and central sleep apnea, caused by a failure of the brain to properly control breathing. Older age, obesity, and male sex are the strongest risk factors.

Sources

  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "CURRENT Medical Diagnosis and Treatment 2020" McGraw Hill Professional (2019)
  5. "Meta-analysis: Continuous Positive Airway Pressure Improves Insulin Resistance in Patients with Sleep Apnea without Diabetes" Annals of the American Thoracic Society (2013)
  6. "Obstructive sleep apnoea syndrome and its management" Therapeutic Advances in Chronic Disease (2015)
  7. "Sleep Pathologies in Depression and the Clinical Utility of Polysomnography" The Canadian Journal of Psychiatry (2010)